补阳还五汤加减方联合尿激酶治疗急性下肢DVT的临床疗效观察  

Efficacy of Modified Buyang Huanwu Decoction Combined with Urokinase for the Treatment of Acute Deep Vein Thrombosis

作　　者：霍景山[1] 韩新峰[1] 吴日钊[1] 庄志浩[1] 吴岷翰[1] 卢彦川[1] 陶世明[1] 

机构地区：[1]广东省佛山市中医院普通外科,广东佛山528000

出　　处：《临床医学工程》2015年第9期1144-1146,共3页Clinical Medicine & Engineering

基　　金：2013年广东省中医药管理局立项课题(20131060)

摘　　要：目的研究补阳还五汤加减方联合尿激酶(urokinase,UK)治疗急性下肢深静脉血栓(deep vein thrombosis,DVT)的临床疗效。方法 40例急性DVT患者随机分为研究组和对照组各20例。所有患者均给予基础治疗,此外,研究组患者采用补阳还五汤加减方联合尿激酶行溶栓抗凝治疗,对照组仅采用尿激酶行溶栓抗凝治疗。观察比较两组治疗过程中的疗效、并发症以及不良反应发生情况,并通过血管彩超了解两组患者的血管再通情况。结果研究组治愈率为80%(16/20),对照组治愈率为50%(10/20),差异有统计学意义(P<0.05);研究组、对照组的总有效率分别为100%、90%,差异无统计学意义(P>0.05)。研究组中,治疗明显有效的患者其疼痛减轻所需时间为(4.20±0.83)天,显著短于对照组治疗明显有效患者的疼痛减轻所需时间(5.10±0.91)天,差异有统计学意义(P<0.05);研究组治疗有效的患者其疼痛减轻所需时间为(3.20±0.89)天,显著短于对照组治疗有效患者的疼痛减轻所需时间(4.00±1.07)天,差异有统计学意义(P<0.05)。研究组患者患肢肿胀完全消退所需时间为(6.75±1.11)天,显著短于对照组的(7.45±0.75)天,差异有统计学意义(P<0.05);研究组治疗有效的患者其患肢肿胀减轻所需时间为(3.75±0.78)天,明显少于对照组治疗有效患者的(4.50±0.82)天,差异有显著统计学意义(P<0.01)。两组均无严重出血并发症发生。结论补阳还五汤加减方联合UK治疗急性DVT疗效显著,安全性好。Objective To evaluate the clinical efficacy of modified Buyang Huanwu decoction combined with urokinase （UK） for the treatment of acute deep vein thrombosis （DVT）. Methods Forty patients with DVT were randomly divided into two groups, with 20 cases in each group. In addition to basic treatment, patients in the study group were treated with modified Buyang Huanwu decoction combined with UK, while the patients in the control group were treated with UK only. The clinical efficacy, complications and adverse reactions during treatment were observed, and the recanalization situation was observed by vascular ultrasound. Results The cure rate of study group was 80%, significantly higher than 50% of control group （P〈0.05）, but there was no statistical intergroup difference in the total effective rate （100 % v s. 90 %）, P 〉0.05. The time for pain relief of obviously effective patients o f study group was （4.20 ± 0.83 ） d, significantly shorter than （5.10 ±_ 0.91） d of obviously effective patients of control group （P 〈0.05）; The time for pain relief of effective patients of study group was （3.20 _± 0.89） d, significantly shorter than （3.20 _± 0.89） d of effective patients of control group （P 〈0.05）. The time for swelling completely subsided of study group was （6.75± 1.11） d, significantly shorter than （7.45 ± 0.75） d of control group （P〈O.05）; The time for swelling completely subsided of effective patients of study group was （3.75 ± 0.78） d, significantly shorter than （4.50 ± 0.82） d of control group （P 〈0.01）. No serious bleeding complication was found in both groups. Conclusions Modified Buyang Huanwu decoction combined with UK for the treatment of acute DVT has significant efficacy and high safety.

关 键 词：补阳还五汤 深静脉血栓 溶栓 尿激酶 低分子肝素 

分 类 号：R2-031[医药卫生—中西医结合] R543.6[医药卫生—中医学]