IVF/ICSI前女性患者心理及生理状态对妊娠结局影响的结构方程模型  

Structural Equation Model of the Effect of Psychological and Physiological Factors on IVF/ICSI Outcomes

作　　者：史潇[1] 徐辉[2] 刘倩倩[1] 李云[1] 全松[1] 

机构地区：[1]南方医科大学南方医院妇产科,广州510515 [2]中山医科大学孙逸仙纪念医院麻醉科

出　　处：《国际生殖健康／计划生育杂志》2015年第5期364-367,共4页Journal of International Reproductive Health/Family Planning

摘　　要：目的:通过结构方程建模对影响体外受精/胞浆内单精子注射(IVF/ICSI)治疗结局的生理及心理因素进行探索。方法:随机选取442例符合纳入条件的患者,填写状态-特质焦虑量表(STAI)、贝克抑郁量表(BDI)、领悟社会支持量表(PSSS)及医学应对方式问卷(MCMQ),同时收集所有患者的社会人口学资料、疾病基础状况及治疗情况等,进行相关分析并建立结构方程模型。结果:胚胎质量、负性心理因素对妊娠结局有直接影响,年龄、基础卵泡刺激素(b FSH)、基础窦卵泡数(AFC)、获卵数、促性腺激素(Gn)启动剂量、Gn使用总量、Gn使用时间对妊娠结局有间接影响。结论:患者生理及心理因素之间存在复杂相关关系,除生物学因素的改善,消除负性心理因素后对改善妊娠结局有一定作用。Objective： To clarify the effect of psychological and physiological factors on IVF/ICSI outcomes by developing a structural equation model. Methods：442 infertility women who met the inclusion criteria were selected randomly as subjects. Psychological questionnaires （STAI, BDI, PSSS and MCMQ） were used to measure psychological status. Data of social demography, basic disease and treatment were also collected. Basic statistical analysis was conducted by SPSS 16.0, and the structural equation model was developed by AMOS20.0. Results：Through the structural equation modeling, we found that the quality of embryos and the psychological states directly influenced the clinical pregnancy outcomes. Age, bFSH, AFC, the number of retrieved oocyte, Gn starting dose, the treatment duration and total dose of Gn indirectly affected the pregnancy outcomes. Conclusions：The crossover effect between psychological and physiological factors were complicated. It is helpful for improving the pregnancy outcomes to remove the negative psychological factors, besides improving biological factors.

关 键 词：生殖技术 辅助 妊娠结局 模型 心理学 模型 理论 结构方程建模 

分 类 号：R714.8[医药卫生—妇产科学]