独活寄生汤治疗膝骨关节炎机制研究及临床应用  

The clinical use and its mechanisms research on angelicae pubescentis and loranthi decoction in KOA treatment

作　　者：吕顺[1] 周军杰[1] 谢晓涛[1] 高文武[1] 陈贤奇[1] 刘铖禕 

机构地区：[1]上海中医药大学附属普陀医院骨科,硕士研究生200062

出　　处：《环球中医药》2015年第9期1149-1152,共4页Global Traditional Chinese Medicine

基　　金：国家中医药管理局中医药重点学科建设项目(2013QK20);上海中医药大学研究生"创新能力培养"专项科研项目(2015YCX14)

摘　　要：独活寄生汤是中医学中治疗风寒湿痹,肝肾两虚,气血不足证的经典方剂之一,随着现代药理研究的不断深入该方已广泛应用于膝骨关节炎治疗。为进一步探讨独活寄生汤治疗膝骨关节炎机制,对近五年来其治疗膝骨关节炎基础文献检索分析,发现其可能通过调控炎性细胞因子、促进软骨细胞增殖、抑制软骨细胞凋亡等方面起到积极作用,从而延缓关节软骨退变,减轻疼痛,改善关节功能等。Angelicae pubescentis and loranthi decoction is one of the most classical prescription in TCM（ Traditional Chinese Medicine TCM ） . It can expel wind-damp, relieve pain, benefit to liver and kidney, and tonify Qi-blood effectively. As the development of pharmacology of TCM, this decoction is widely used in the treatment of KOA. In order to further investigate the mechanisms of angelicae pubescentis and loranthi decoction in KOA, we summarized the basic researches on the decoction in treating KOA in recent five years. We found that it may play an important role in regulating inflammatory, stimulating cartilage proliferation, and inhibiting cartilage apoptosis, thus it can delay articular cartilage degeneration, relieve pain, and improve joint function and so on.

关 键 词：膝骨关节炎 独活寄生汤 综述 

分 类 号：R684.3[医药卫生—骨科学]