综述细胞外信号调节激酶1/2信号通路与肝肾亏虚型膝骨关节炎的相关性  

Review on correlation between ERK1/2 signaling pathway and knee osteoarthritis with syndrome of deficiency of liver and kidney

作　　者：陈泽华[1] 林海英[1] 李楠[1] 

机构地区：[1]福建中医药大学,福州350122

出　　处：《中华中医药杂志》2015年第9期3207-3210,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：福建省卫生厅中医药科研项目(No.wzgs201301);福建省中青年教师教育科研重点项目(科技A类;No.JA13153)~~

摘　　要：细胞外信号调节激酶(ERK)是丝裂原活化蛋白激酶家族中的一个重要亚型,细胞外信号调节通路在膝骨关节炎发病过程中持续表达,对软骨细胞的增殖、凋亡有重要调节作用。肝肾亏虚为膝骨关节炎的常见证型,而补肝肾中药能有效调控细胞外信号调节激酶1/2(ERK1/2)的表达以达到治疗膝骨关节炎的效果。研究ERK1/2与肝肾亏虚型膝骨关节炎的关系,能为揭示该病的发病机制和指导其临床治疗提供新依据和思路。Extracellular signal-regulated kinase （ERK） is an important subtype of mitogen-activated protein kinase （MAPK） family. Continuous expression of ERK pathway in the pathogenesis of knee osteoarthritis （KOA） plays an important role in regulating proliferation and apoptosis of chondrocytes. The common syndromeof KOA is syndrome of deficiency of liver and kidney, and drugs ofnourishing liver and kidneycan treat KOA through regulate the expression of ERK1/2 effectively. Studying the correlation between ERK1/2 signaling pathway and knee osteoarthritis with syndrome of deficiency of liver and kidneycan provides new evidences and ideas for revealing pathogenesis and guiding clinical treatment of this disease.

关 键 词：骨关节炎 软骨细胞 细胞外信号调节激酶 综述 肝肾亏虚型 

分 类 号：R274.9[医药卫生—中西医结合]