全麻患者意识消失与意识恢复时丙泊酚效应室浓度的研究  

作　　者：陈培 肖纯 施海滨[2] 朱彬 

机构地区：[1]杭州市妇产科医院麻醉科,310008 [2]杭州市第一人民医院,310006

出　　处：《浙江临床医学》2015年第10期1696-1698,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 观察全麻患者意识消失与意识恢复时丙泊酚效应室浓度之间的关系,寻找指导丙泊酚靶控输注（TCI）方案的个体化指标.方法 拟与全麻下行择期手术患者30例,丙泊酚TCI诱导与维持麻醉,分别记录患者意识消失与意识恢复时丙泊酚的效应室浓度.结果 意识消失时丙泊酚效应室浓度平均为（1.7±0.8） μg/ml,意识恢复时丙泊酚效应室浓度平均为（1.9±0.7）μg/ml,与意识消失时丙泊酚效应室浓度比较意识恢复时丙泊酚效应室浓度较大（p＜0.05）,二者密切相关（R=0.91,P＜0.01）.二者之差的均值为（0.29±0.25） μg/ml,95％可信区间为（0.16,0.34）μg/ml.结论 患者意识消失时丙泊酚的效应室浓度可以作为手术结束时调节丙泊酚TCI的个体化指标.Objective To investigate the relationship of propofol effect-site concentration between the loss of consciousness and the recovery of consciousness, and find out the individualized indicator of propofol target controlled infusion （ TCI ） . Methods Thirty patients scheduled for elective surgery under general anesthesia were enrolled. The value of propofol effect-site concentration at consciousness recovery and disappearance was recorded respectively. Results The effect-site concentration of propofol was （ 1.7 ± 0.8 ） μ g/ml and （ 1.9 ±0.7 ） μ g/ml at the loss of consciousness and recovery of consciousness occurred respectively. The effect-site concentration of propofol was lower at the loss of consciousness （ P 〈0,05 ） , but they had a positive correlation （ R=0.91 P〈0.01 ） . The difference value was （ 0.29 ± 0.25 ） μ g / ml and 95% confidence interval was （ 0.16, 0.34 ） μg/ml. Conclusions The effect-site concentration of propofol can be regarded as an individual indicator for adjusting propofol TCI.

关 键 词：丙泊酚 意识消失 意识恢复 效应室浓度 

分 类 号：R969.1[医药卫生—药理学]