中枢神经系统狼疮的临床研究进展  

Central nervous system lupus: an update

作　　者：沈思钰[1] 傅晓东[2] 王文健[2] 

机构地区：[1]南京军区南京总医院中西医结合科,南京医学博士210002 [2]复旦大学中西医结合研究所,上海200040

出　　处：《医学研究生学报》2015年第9期973-977,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30672735);上海市科学技术委员会科研计划课题(12401905100)

摘　　要：中枢神经系统受累是神经精神狼疮最常见的损害。文中在文献回顾的基础上,重点分析中枢神经系统狼疮的临床表现、发病机制、诊断和治疗,随着神经免疫学、神经影像学及临床治疗学的进展,早期诊断、积极评估及目标治疗可以明显控制发作、改善生存质量及提高预期寿命。未来的方向将可能更关注于患者的临床注册、疾病活动性评价及难治性病例干预的研究。At present, central nervous system involvement is the most common in neuropsychiatric lupus. This article discusses the research status of central nervous system lupus in the past few years which include characteristics of clinical presentation, etiopathological mechanism, neuroimaging diagnosis and therapeutic strategy. Actually, the advanced technology, especially neuroimmunology and neuroimaging, in combination with early diagnosis, effective assessment and treat to target strategy could decrease global disease activity, ameliorate quality of life and increase life expectancy. Furthermore, the prospective researches should be paid more attention in lupus registries, neuropsychiatric questionnaires, damage index and improvement of severe refractory cases in clinic.

关 键 词：中枢神经系统狼疮 神经精神狼疮 系统性红斑狼疮 神经免疫学 神经影像学 目标治疗 

分 类 号：R593.241[医药卫生—内科学]