新型缺氧保护因子胞红蛋白的研究进展  

Protective effect of cytoglobin under hypoxia: An update

作　　者：李维[1] 范文静[2] 屈顺林[1] 

机构地区：[1]南华大学医学院病理生理学教研室,衡阳医学硕士研究生421001 [2]南华大学附属第二医院急诊科,衡阳421001

出　　处：《医学研究生学报》2015年第9期978-983,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81100212)

摘　　要：作为珠蛋白家族的第四名成员,胞红蛋白在缺氧条件下的表达明显增强。其在生物体内分布广泛,具有多种重要的生物学功能,如抗氧化应激、抗纤维化、神经保护作用以及在心血管疾病、癌症等和缺氧有关的疾病中起到一定的保护作用。文中综合了近年来的研究成果,就胞红蛋白的结构与分布,抗纤维化、抗癌、促进肌肉再生等相关生理功能以及在缺氧下的表达调节和表达机制作一综述。As the fourth member of the globin family, cytoglobin （CYGB） is a hypoxia-induced gene, and its expression is upregulated under hypoxia. CYGB is widely distributed in the living body and has a variety of physiological functions, such as anti-oxidative stress, anti-fibrosis, and neuroprotection. It also plays a protective role in cardiovascular disease, cancer, and other hypoxia-related diseases. This article presents an overview on the structure and distribution of CYGB, its physiological functions of anti-fibrosis, anti-cancer and muscle regeneration, and the regulation and the mechanism of its expression under hypoxia.

关 键 词：胞红蛋白 生理功能 缺氧 表达机制 

分 类 号：Q51[生物学—生物化学]