膨体聚四氟乙烯人工血管修复四肢干动脉缺损的效果  

Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries

作　　者：张汉江[1] 王志维[1] 

机构地区：[1]武汉大学人民医院心血管外科,湖北省武汉市430000

出　　处：《中国组织工程研究》2015年第34期5496-5500,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:研究已证明膨体聚四氟乙烯人工血管具有良好的疏水性表面、抗水渗透性及生物耐久性。目的:观察膨体聚四氟乙烯人工血管移植修复创伤性四肢干动脉缺损的效果。方法:纳入38例创伤性四肢干动脉缺损患者,其中男30例,女8例,年龄17-61岁,予以常规补液、抗休克治疗、抗炎、清创处理后,均实施膨体聚四氟乙烯人工血管移植修复治疗。修复后随访12个月,了解患者修复后患肢恢复情况和血管通畅情况等。结果与结论:实施膨体聚四氟乙烯人工血管移植修复后,患者血管均全部通畅,未出现死亡和截肢病例,患肢均恢复正常血运,未发生血管吻合口感染,影像学检查显示血管通畅率达到100%。修复后随访12个月,血管内超声检查显示人工血管内壁均处于光滑状态,未出现明显附壁血栓、吻合口位狭窄现象,血管通畅率达到92%(35/38),未发生与人工血管材料相关的不良反应。表明利用膨体聚四氟乙烯人工血管移植修复创伤性四肢干动脉缺损具有良好的表面抗凝血性能及长期通畅效果。BACKGROUND：Vascular grafts made of expanded polytetrafluoroethylene have been shown to have highly hydrophobic surface characterized by resistance to water penetration and biological durability. OBJECTIVE：To investigate the effects of vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries. METHODS：Thirty-eight patients with peripheral arterial injuries, consisting of 30 males and 8 females, aged 17-61 years, were included in this study. After conventional fluid infusion, anti-shock treatment, anti-inflammation, and debridement, they received implantation of vascular grafts made of expanded polytetrafluoroethylene. A 12-month folow-up observation was performed to investigate the recovery of affected limbs and vascular patency in patients. RESULTS AND CONCLUSION：After implantation of vascular grafts made of expanded polytetrafluoroethylene, al vessels were unblocked and no cases died or had limbs amputated. Blood supply of al affected limbs recovered to normal and there was no vascular anastomotic infection. Imaging results showed that vascular patency rate was 100%. Ultrasound examination results showed that at the end of the folow-up period, the inner wal of the vascular grafts was smooth, obvious mural thrombus or anastomotic stenosis did not occur in any case, vascular patency rate was 92% （35/38）, and no adverse reactions related to artificial vessels were observed. These findings suggest that vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries exhibit striking surface anticoagulant property and long-term patency.

关 键 词：生物材料 材料相容性 人工血管 膨体聚四氟乙烯 抗凝血性能 血管通畅 

分 类 号：R318[医药卫生—生物医学工程]