新型β钛合金Ti_(35)Nb_3Zr_2Ta在人工关节假体应用中的生物相容性  

Biocompatibility of Ti_(35)Nb_3Zr_2Ta, a new beta-titanium alloy, as joint prosthesis material

作　　者：段永刚[1] 丁英奇[1] 张龙[1] 刘玉章[1] 唐晓龙[1] 

机构地区：[1]河北北方学院附属第二医院骨外科,河北省张家口市075100

出　　处：《中国组织工程研究》2015年第34期5536-5540,共5页Chinese Journal of Tissue Engineering Research

基　　金：张家口科技局与地震局自筹项目(1321120D)~~

摘　　要：背景:目前被广泛应用于人体关节置换的钛合金为Ti6Al4V,但其弹体模量高于人体骨,导致人工关节假体的稳定性差。而新型β钛合金Ti35Nb3Zr2Ta弹性模量较低,或许能成为新一代生物相容性较好的人体关节假体材料。目的:探讨新型β钛合金Ti35Nb3Zr2Ta在人工关节假体应用的生物相容性。方法:应用计算机检索自万方数据库、中国知网和Pub Med文献数据库,检索时间范围2010至2015年,以"新型β钛合金;人工关节假体;生物相容性"为检索词,检索医用人工关节假体材料的应用现状及新型β钛合金Ti35Nb3Zr2Ta在人工关节假体应用的生物相容性的研究。结果与结论:与Ti6Al4V相比,Ti35Nb3Zr2Ta表面粗糙度较高,表面接触角较小,碱性磷酸酶活性以及成骨细胞的钙沉积量明显高于Ti6Al4V,具有良好的生物相容性,可以考虑在人工关节假体领域中进一步广泛应用。BACKGROUND：Ti6Al4V is a titanium aloy that is widely used in human joint replacement, but its modulus of elasticity is greater than human bone, resulting in the bad stability of the prosthesis. Ti35Nb3Zr2Ta, a new βtitanium aloy, has a lower modulus of elasticity, and maybe becomes a new-generation human joint prosthesis material that has a better biocompatibility. OBJECTIVE：To study the biocompatibility of Ti35Nb3Zr2Ta in prosthesis. METHODS：Wanfang, CNKI and PubMed databases were retrieved using a computer with “new β titanium;prosthesis; biocompatible” as keywords, and the retrieval time ranged from 2010 to 2015. Articles focusing on current application status for medical prosthesis materials and the biocompatibility of Ti35Nb3Zr2Ta in prosthesis were selected. RESULTS AND CONCLUSION：Compared with Ti6Al4V, Ti35Nb3Zr2Ta has higher surface roughness and smaler surface contact angle; the alkaline phosphatase activity and amount of calcium deposits in osteoblasts cultured at Ti35Nb3Zr2Ta is significantly higher than that at Ti6Al4V. Ti35Nb3Zr2Ta has good biocompatibility, and can be considered to be widely used as joint prosthesis material further.

关 键 词：生物材料 材料相容性 新型β钛合金 人工关节假体 生物相容性 表面粗糙度 碱性磷酸酶活性 矿化 金属材料 

分 类 号：R318[医药卫生—生物医学工程]