乙型肝炎病毒携带者外周血IFN-γ、IL-32和IL-6的变化及临床相关性  

Changes and clinic correlation of IFN-γ,IL-32 and IL-6 levels in peripheral blood of hepatitis B virus carriers

作　　者：李彩东[1] 杨勇卫[1] 李惠军[1] 田鹏飞[1] 吴斌[1] 

机构地区：[1]兰州市第二人民医院肝病研究所,甘肃兰州730046

出　　处：《国际检验医学杂志》2015年第18期2622-2624,共3页International Journal of Laboratory Medicine

基　　金：兰州市科技发展指导性计划项目(2014-ZD-07)

摘　　要：目的探讨乙型肝炎病毒(HBV)携带者外周血细胞因子γ干扰素(IFN-γ)、白细胞介素-32(IL-32)和白细胞介素-6(IL-6)水平变化及其与肝功能水平和HBV DNA载量的相关性。方法收集60例HBV携带者空腹血清标本,其中慢性HBV携带者39例,非活动性乙型肝炎表面抗原(HBsAg)携带者21例,另收集体检健康者50例(对照组),检测血清IFN-γ、IL-32和IL-6水平、HBV DNA载量及血清肝功能水平,并进行相关性分析。结果与对照组相比,慢性HBV携带者和非活动性HBsAg携带者外周血IFN-γ、IL-32和IL-6水平均升高,差异均有统计学意义(P<0.05);中病毒载量慢性HBV携带者外周血IFN-γ、IL-32和IL-6水平均高于低病毒载量与高病毒载量携带者,但差异均无统计学意义(P>0.05);HBV携带者外周血IL-32水平与AST水平呈正相关(r=0.32,P<0.05),与ALB水平呈负相关(r=-0.27,P<0.05)。结论细胞因子IFN-γ、IL-32和IL-6在慢性HBV感染过程中可能起重要作用,可作为评估HBV携带者肝脏炎症严重程度的重要指标。Objective To explore changes of levels of interferon‐γ（IFN‐γ） ,interleukin‐32（IL‐32） and interleukin‐6（IL‐6） in pe‐ripheral blood and the correlation between peripheral IFN‐γ,IL‐32 ,IL‐6 and liver function level and hepatitis B virus（HBV） DNA load in HBV carriers .Methods Sixty HBV carriers ,including 39 cases of chronic HBV carriers and 21 cases of inactive hepatitis B surface antigen（HBsAg） carriers ,and 50 healthy individuals were collected .Serum levels of IFN‐γ,IL‐32 and IL‐6 ,the amount of HBV DNA and liver function were detected ,and clinical correlations were analysed .Results Compared with the control group ,ser‐um levels of IFN‐γ,IL‐32 and IL‐6 of chronic HBV carriers and inactive HBsAg carriers were significantly increased （P〈0 .05） . Compared with chronic HBV carriers with low amount of HBV DNA loads and high amount of HBV DNA loads ,chronic HBV car‐riers with medial HBV DNA loads had higher serum levels of IFN‐γ,IL‐32 and IL‐6 ,but no statistically significant differences were observed（P〉0 .05） .There was positive correlation between IL‐32 level and ALT level （r=0 .32 ,P〈0 .05） ,and negative correla‐tion between IL‐32 level and ALB level（r= -0 .27 ,P〈0 .05） .Conclusion IFN‐γ,IL‐32 and IL‐6 may play important roles in chro‐nic HBV infection ,the levels of IFN‐γ,IL‐32 and IL‐6 could be used as important indicators to assess the severity of inflammation in HBV carriers .

关 键 词：乙型肝炎病毒携带者 Γ干扰素 白细胞介素-32 白细胞介素-6 

分 类 号：R512.62[医药卫生—内科学]