锌对婴幼儿肺炎患儿免疫功能的影响  

Effects of zinc on immune function in children with infantile pneumonia

作　　者：黄艳[1] 裴雪梅[1] 卢国煊 张炜灵[1] 潘彩金[1] 

机构地区：[1]深圳市宝安区人民医院儿科,广东深圳518101

出　　处：《国际检验医学杂志》2015年第18期2645-2646,2649,共3页International Journal of Laboratory Medicine

基　　金：深圳市宝安区科技计划项目(2013115)

摘　　要：目的分析锌对婴幼儿肺炎患儿免疫功能的影响。方法选取2014年5～7月收治的婴幼儿肺炎患儿96例随机分成锌辅助治疗组和常规治疗组,各48例。常规治疗组给予常规治疗措施,锌辅助治疗组在常规治疗的同时给予锌制剂。分别在治疗前、治疗后对两组各进行一次血清锌水平和免疫功能检测。另选取同期体检健康婴幼儿40例作为健康对照组。对3组的血清锌水平及免疫功能进行统计分析。结果治疗前两组患儿血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋/CD8＋细胞比值均低于健康对照组,CD8＋细胞百分比均高于健康对照组,差异均有统计学意义（P〈0.05）;但两组患儿各指标比较差异均无统计学意义（P〉0.05）。锌辅助治疗组治疗后血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋/CD8＋细胞比值均高于常规治疗组,CD8＋细胞百分比低于常规治疗组,差异均有统计学意义（P〈0.05）;而与健康对照组比较,血清锌、IgA、IgM、IgG水平仍较低,差异均有统计学意义（P〈0.05）。常规治疗组治疗后血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋/CD8＋细胞比值仍低于健康对照组,CD8＋细胞百分比仍高于健康对照组,差异均有统计学意义（P〈0.05）。结论锌可以有效地改善婴幼儿肺炎患儿的免疫功能,有利于缩短患儿的治疗时间,减少不良结局的发生。Objective To analyse effects of zinc on immune function in children with infantile pneumonia .Methods A total of 96 children with infantile pneumonia selected from May to July 2014 were randomly divided into zinc supplementary treatment group and routine treatment group ,with 48 cases in each group .Routine treatment group was given conventional treatment ,while the zinc supplementary treatment group was received conventional treatment combined with zinc supplement .The serum level of zinc and immune function were detected before and after treatment ,respectively .Other 40 healthy infants received physical examination were contemporarily selected as healthy control group .Results Before treatment ,the levels of serum zinc ,IgA ,IgM and IgG ,percentages of CD3＋ ,CD4＋ cells and the CD4＋ /CD8＋ ratio in the two groups of children with infantile pneumonia were lower than those in the healthy control group ,while percentage of CD8＋ cells was lower than that in the healthy control group ,had statistically significant differences（P〈0 .05） .While no statistically significant differences of indicators mentioned above were found between the zinc sup‐plementary treatment group and routine treatment group before treatment（P〉 0 .05） .After treatment ,the levels of serum zinc , IgA ,IgM and IgG ,percentages of CD3＋ ,CD4＋ cells and the CD4＋ /CD8＋ ratio in the zinc supplementary treatment group were higher than those in the routine treatment group ,and percentage of CD8＋ cells was lower than that in the routine treatment group , had statistically significant differences（P〈0 .05）;while compared with the healthy control group ,levels of serum zinc ,IgA ,IgM , IgG were still lower ,had statistically significant differences（P〈0 .05） .After treatment ,levels of serum zinc ,IgA ,IgM ,IgG ,per‐centages of CD3＋ ,CD4＋ cells and the CD4＋ /CD8＋ ratio in the routine treatment group were still lower than those in the healthy control group ,and percentage of CD8＋ cells was still higher

关 键 词：锌 婴幼儿肺炎 免疫功能 

分 类 号：R725.6[医药卫生—儿科]