复方三七止痛颗粒有效成分提取工艺的研究  

Optimization of the Extraction Technology of Active Ingredients from Compound Angelica Granule for Relieving Pain

作　　者：陈锐 杨建龙 

机构地区：[1]吉林省长春市食品药品检验所,长春130117

出　　处：《海峡药学》2015年第8期7-9,共3页Strait Pharmaceutical Journal

摘　　要：目的优选复方中当归等药材中挥发性成分的提取工艺,以及三七、人参等药材脂溶性成分的提取工艺。方法采用单因素试验,以挥发油提取率为评价指标,优选挥发油提取工艺;采用正交设计试验,以总皂苷的含量为考核指标,优选药材脂溶性的提取工艺。结果挥发油最佳提取工艺条件为:药材粉碎过20目筛,不浸泡,加10倍量水提取5h。脂溶性成分最佳工艺为:药材加入8倍量的70%乙醇,回流提取3次,每次1h。结论提取工艺设计合理,结果稳定,适合于工业化生产。OBJECTIVE To optimize the extraction technology of volatile active substance from Angelica and other herbs,as well as fat-soluble ingredients from Panax, Ginseng and other herbs.METHODS The extraction technology of volatile active substance was optimized by single factor experiment with the volume of volatile oil;The extraction technology of fat-soluble ingredients was optimized by orthogonal design with the contents of total sapo-nins.RESULTS The optimum extraction conditions of the volatile oil were as follows：crushing the drugs into 20 meshes,no soaking,adding 10 times water into the herbs and extracting the medicines for 5 hours.The optimum ex-traction conditions of fat-soluble ingredients as follows：8 times of 70%alcohol was added,reflux extraction was per-formed threetimes and 1h in each time.CONCLUSION The extraction process design is reasonable,the results are stable and suitable for industrial production.

关 键 词：挥发油 回流提取 总皂苷 正交试验 

分 类 号：TQ460.4[化学工程—制药化工] R97[医药卫生—药品]