盐酸纳美芬在老年腹腔镜胆囊切除术中的应用  

Application of Nalmefene in Geriatric Laparoscopic Cholecystectomy

作　　者：封光[1] 

机构地区：[1]徐州医学院附属医院麻醉科,徐州221002

出　　处：《海峡药学》2015年第8期97-98,共2页Strait Pharmaceutical Journal

摘　　要：目的：观察盐酸纳美芬对行腹腔镜胆囊切除术的影响。方法择期腹腔镜下胆囊切除术老年患者30例，随机均分为生理盐水对照组（ A组）和盐酸纳美芬组（ B组）。 B组术毕时接受静脉注射0．25μg？ kg－1盐酸纳美芬，A组则给予相同容量的生理盐水。记录两组患者个时间段的心率（HR）和平均动脉压（MAP），观察苏醒时间、脑电双频指数（BIS）值，转入麻醉恢复室（PACU）后躁动发生情况和疼痛VAS分级。结果与A组比较，盐酸纳美芬组在T2～T5时段MAP和HR明显降低（P＜0．05）；自主呼吸恢复时间、睁眼时间和拔管时间均明显降低（P＜0．05）；T3～T4时间段BIS值明显增高（P＜0．05）；拔管后转入PACU期间躁动分级和躁动发生率也明显降低（P＜0．05），VAS临床评定优良率两组间无统计学差异。结论盐酸纳美芬在老年腹腔镜胆囊切除术中可以缩短患者术后苏醒时间，减少围麻醉期不良事件的发生率。OBJECTIVE To investigate the effects of nalmefene on aged patients receiving laparoscopic chole-cystectomy.METHODS 30casesofagedpatientswererandomlydividedinto2groups：controlgroup（Agroup） and nalmefene group （ B group）.Patients in group B received 0.25μg？ kg -1 nalmefene and patients in group A re-ceived saline of equivalent capacity at the induction of anesthesia.HR and MAP were observed on defferent time.BIS,awakening time and operation time were all recorded.Moreover,the occurrence of agitation and the postop-erative VAS scale were observed in PACU.RESULTS Nalmefene significantly reduced HR and MAP during T2 ~T5 period and increased BIS during T3 ~T4 period compared with control group.Moreover,nalmefene obviously de-creased the occurrence of agitation.There were no significant differences of VAS scale between control and nalmefene group.CONCLUSION Nalmefene infusion in geriatric laparoscopic cholecystectomy can reduce the recovery time of anesthesia and the adverse reaction.

关 键 词：盐酸纳美芬 腹腔镜胆囊切除 

分 类 号：R969.4[医药卫生—药理学]