血清维生素D水平与桥本甲状腺炎的相关性分析  

Correlation analysis between serum vitamin D and Hashimoto's thyroiditis

作　　者：李娜[1] 蒋筠[1] 严率[1] 方芳[1] 顾丽萍[1] 彭永德[1] 王育璠[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢科,上海200080

出　　处：《世界临床药物》2015年第9期591-595,共5页World Clinical Drug

基　　金：国家自然科学基金[DAX1基因调节胆汁酸受体FXR活性机制研究(编号:81100616)]

摘　　要：目的 观察桥本甲状腺炎患者血清维生素D的含量,探讨维生素D与桥本甲状腺炎的关系。方法 选取2013年7月至2014年3月在我院就诊的桥本甲状腺炎患者50例,同时选取正常健康对照者56例。收集性别、年龄、身高、体重、体重指数（BMI）、血压、血糖、血脂、钙、磷、甲状旁腺激素（PTH）、甲状腺激素、甲状腺自身抗体及25羟维生素D3[25（OH）D3]等临床资料。比较两组维生素D含量,并对相关指标进行分析。结果 与正常对照组相比,桥本甲状腺炎患者血清25（OH）D3水平降低（P〈0.05）,维生素D不足发生比例升高（P〈0.05）;桥本甲状腺炎患者促甲状腺激素水平升高（P〈0.01）,发生亚临床甲减的比例较高（P〈0.01）。二元Logistic回归模型分析表明,维生素D为桥本甲状腺炎的保护因素（OR值0.969,P〈0.01,95%CI为0.946~0.991）,BMI为桥本甲状腺炎的危险因素（OR值1.200,P〈0.05,95%CI为1.016~1.417）。结论 维生素D缺乏在桥本甲状腺炎患者中发生率较高,维生素D缺乏可能会增加桥本甲状腺炎的风险。Objective To determine vitamin D levels in patients with Hashimoto＇s thyroiditis （HT）, then to explore the relationship between vitamin D and HT. Methods Fifty patients with HT and fifty-six healthy people in our hospital from July 2013 to March 2014 were selected as HT group and control group. Blood glucose, serum lipid profile, 25-hydroxyvitamin D3, calcium, phosphorus, parathyroid hormone （PTH）, thyroid hormone and antithyroid antibodies were measured. The relationship between vitamin D and HT was analyzed. Results Compare with those in control group, the serum 25-hydroxyvitamin D3 levels in HT group were lower （P 〈 0.05）, and the proportion of vitamin D deficiency was higher （P 〈 0.05） ; The TSH levels and the proportion of subclinical hypothyroidism in HT group were higher （P 〈 0.01）. Logistic regression analysis demonstrated that vitamin D was associated with HT （OR 0.969, P 〈 0.01, 95% CI 0.946- 0.991）, and BMI was a risk factor for HT （OR 1.200, P 〈 0.05, 95% CI 1.016-1.417）. Conclusion HT patients have a high prevalence of vitamin D deficiency. Vitamin D deficiency is associated with HT.

关 键 词：维生素D 桥本甲状腺炎 自身免疫性甲状腺疾病 

分 类 号：R518.4[医药卫生—内科学]