γ-干扰素辅助治疗结核性胸膜炎及自然杀伤T细胞表达研究  

Studies on interferon gamma for tuberculous pleurisy adjuvant treatment and the expression of nature kill T cell

作　　者：李登瑞[1] 杨永辉[2] 朱桂云[2] 陈宁[2] 李晓霞[2] 李辉[3] 李志惠[4] 

机构地区：[1]河北省胸科医院消化内科,石家庄050041 [2]河北省胸科医院病理科,石家庄050041 [3]河北省胸科医院胸外科,石家庄050041 [4]河北省胸科医院结核一科,石家庄050041

出　　处：《世界临床药物》2015年第9期596-599,共4页World Clinical Drug

摘　　要：目的探讨应用γ-干扰素(IFN-γ)辅助治疗结核性胸膜炎患者的疗效并研究NKT细胞表达情况及意义。方法纳入本研究的71例结核性胸膜炎患者随机分成两组(甲组和乙组),甲组采用常规四联抗结核治疗方案,乙组在常规疗法基础上加用重组IFN-γ治疗,另选取31例健康体检人员作为正常对照组(丙组),并通过流式细胞术检测患者与正常对照组NKT的细胞表达,以SPSS19.0统计学软件分析上述指标之间的差异。结果乙组疗效优于甲组,差异有统计学意义(P<0.05)。结核性胸膜炎患者血液和胸腔积液中NKT细胞表达量低于正常对照组,差异有统计学意义(P<0.05)。结论常规疗法辅助IFN-γ治疗结核性胸膜炎疗效显著,优于常规治疗方案。Objective To explore the curative effect of IFN-γ in the auxiliary treatment of tuberculosis pleurisy patients and to investigate nature kill T （NKT） cell expression and its clinical significance. Methods Total of 71 tuberculous pleurisy patients were randomly divided into two groups： group A was treated with conventional quadruple anti-tuberculosis therapy; group B was treated with conventional therapy plus recombinant IFN-Y auxiliary treatment. The NKT cells express changes between patients and normal persons were measured by flow cytometry, and analyzed by SPSS19.0 series meter science software. Results The efficacy of group B was better than that of group A, and the difference was statistically significant （P 〈 0.05）. The NKT cells expression in tuberculosis pleurisy patients＇ blood and pleural effusion was lower than that of normal people, the difference was statistically significant （P 〈 0.05）. Conclusion The curative effect of tuberculosis pleurisy treatment combined with auxiliary IFN-γ is superior to conventional therapy.

关 键 词：结核性胸膜炎 Γ-干扰素 自然杀伤T(NKT)细胞 

分 类 号：R521.7[医药卫生—内科学] R978.7[医药卫生—临床医学]