血压昼夜节律及晨峰血压对老年认知功能的影响  

Effect of circadian rhythm and morning surge of blood pressure on cognitive function in elderly patients with hypertension

作　　者：邢云利[1] 周震[2] 黄辛[1] 王翠英[1] 黄樱硕[1] 唐梅[1] 孙颖[1] 

机构地区：[1]首都医科大学附属北京友谊医院老年心内科,北京100050 [2]首都医科大学生物医学工程学院,北京100069

出　　处：《中华老年多器官疾病杂志》2015年第8期593-597,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：北京市保健科研课题（京09-02）;首都医科大学基础和临床科研合作基金资助项目（13JK57）

摘　　要：目的：探讨血压昼夜节律对高龄高血压患者认知功能的影响。方法入选2013年6月至2014年8月期间在北京友谊医院老年心内科住院的96例高龄高血压患者（年龄≥80岁），根据简易精神状态量表（MMSE）评分，将其分为轻度认知功能障碍组（MCI组，35例）和认知功能正常组（对照组，61例）。比较两组患者的一般情况、合并症，以及动态血压监测指标。结果 MCI组患者与对照组的24h平均收缩压（24h SBP）分别为（131.14±12.61）和（131.00±13.17）mmHg、24h平均舒张压（24h DBP）分别为（65.74±7.35）和（64.08±8.39）mmHg，两组比较差异均无统计学意义（P＞0.05）。两组昼间平均收缩压（dSBP）、昼间平均舒张压（dDBP）、夜间平均收缩压（nSBP）、夜间平均舒张压（nDBP）比较，差异也无统计学意义（P＞0.05）。但MCI组晨峰血压与对照组比较明显升高[（8.69±12.64） vs （4.08±12.78）mmHg，P＜0.05]。结论清晨血压升高与高龄高血压患者认知功能受损有关。ObjectiveTo determine the effect of circadian rhythm of blood pressure on cognitive function in the very old patients with hypertension.Methods A total of 96 senile hypertensive patients （older than 80 years old） admitted in our department from June 2013 to August 2014 were recruited in this study. According to the results of Mini-Mental State Examination （MMSE）, the patients were divided into normal cognitive function group （control group,n=61） and mild cognitive impairment group （MCI group,n=35）. The general conditions, complications and ambulatory blood pressure parameters were compared between the 2 groups.Results There was no significant difference in 24-hour systolic blood pressure （24hSBP） and 24-hour diastolic blood pressure （24hDBP） between the 2 groups [（131.14±12.61）vs （131.00±13.17）mmHg, and （65.74±7.35）vs （64.08±8.39）mmHg,P〉0.05）. No difference was found either in day SBP （dSBP）, day DBP （dDBP）, night SBP （nSBP） and night DBP （nDBP） between the 2 groups （P〉0.05）. However, morning surge in blood pressure was significantly higher in MCI group than in control group [（8.69±12.64）vs （4.08±12.78）mmHg,P〈0.05].Conclusion Higher morning blood pressure is associated with cognitive impairment in the very old patients with hypertension.

关 键 词：老年人 80以上 高血压 认知障碍 血压变异 清晨血压 

分 类 号：R592[医药卫生—老年医学] R544.1[医药卫生—内科学]