Screening of antidiabetic and antioxidant activities of medicinal plants  

作　　者：Amal Bakr Shori 

机构地区：[1]King Abdulaziz University, Faculty of Science, Department of Biological Sciences

出　　处：《Journal of Integrative Medicine》2015年第5期297-305,共9页结合医学学报（英文版）

摘　　要：Diabetes is a common metabolic disorder characterized by abnormally increased plasma glucose levels. Postprandial hyperglycemia plays an essential role in development of type-2 diabetes. Inhibitors of carbohydrate-hydrolyzing enzymes （such as a-glucosidase and α-amylase） offer an effective strategy to regulate/prevent hyperglycemia by controlling starch breakdown. Natural α-amylase and α-glucosidase inhibitors, as well as antioxidants from plant-based sources, offer a source of dietary ingredients that affect human physiological function in order to treat diabetes. Several research studies have investigated the effectiveness of plant-based inhibitors of α-amylase and α-glucosidase, as well as their antioxidant activity. The aim of this review is to summarize the antidiabetic and antioxidant properties of several medicinal plants around the world. Half inhibitory concentration （IC50, for enzyme suppression） and half effective concentration （EC50, for antioxidant activity） values of less than 500ug/mL were defined as the most potent plant-based inhibitors （in vitro） and are expected to provide interesting candidates for herbal treatment of diabetes, as foods, supplements, or refined drugs.Diabetes is a common metabolic disorder characterized by abnormally increased plasma glucose levels. Postprandial hyperglycemia plays an essential role in development of type-2 diabetes. Inhibitors of carbohydrate-hydrolyzing enzymes （such as a-glucosidase and α-amylase） offer an effective strategy to regulate/prevent hyperglycemia by controlling starch breakdown. Natural α-amylase and α-glucosidase inhibitors, as well as antioxidants from plant-based sources, offer a source of dietary ingredients that affect human physiological function in order to treat diabetes. Several research studies have investigated the effectiveness of plant-based inhibitors of α-amylase and α-glucosidase, as well as their antioxidant activity. The aim of this review is to summarize the antidiabetic and antioxidant properties of several medicinal plants around the world. Half inhibitory concentration （IC50, for enzyme suppression） and half effective concentration （EC50, for antioxidant activity） values of less than 500ug/mL were defined as the most potent plant-based inhibitors （in vitro） and are expected to provide interesting candidates for herbal treatment of diabetes, as foods, supplements, or refined drugs.

关 键 词：medicinal plants Α-AMYLASE Α-GLUCOSIDASE ANTIOXIDANT review 

分 类 号：R285[医药卫生—中药学]