胎盘间充质干细胞的应用研究  

Application of placental mesenchymal stem cells

作　　者：牛婷[1] 李爱斌[1] 曹景云[1] 沈兰[1] 陈力[1] 

机构地区：[1]武汉大学人民医院生殖中心,湖北省武汉市430060

出　　处：《中国组织工程研究》2015年第32期5236-5242,共7页Chinese Journal of Tissue Engineering Research

基　　金：湖北省自然科学基金(2014CFB206);课题名称:胎盘干细胞修复大鼠受损子宫内膜有效性及可行性的研究~~

摘　　要：背景:胎盘间充质干细胞因其具有来源广泛、免疫原性低、不涉及伦理问题等优点成为种子细胞的新来源。目的:阐述胎盘间充质干细胞的来源、生物学特性及应用最新研究进展。方法:检索Pub Med、ScienceD irect、Ovid SP、CNKI数据库相关文章,检索时限为2003至2015年,英lacenta文检索词为"P,Mesenchymal stem cells,The placenta mesenchymal stem cells,Cell transplantation,Application mechanism",中文检索词为"胎盘,间充质干细胞,胎盘间充质干细胞,细胞移植,应用机制",从中筛选出与主题相关且论据可靠的部分文献,最终纳入57篇文章进行归纳综述。结果与结论:目前已成功分离培养出胎盘间充质干细胞,并对其生物学特性进行研究,证明其具有干细胞源性及多向分化潜能。目前有较多关于胎盘间充质干细胞应用于实验动物及临床的研究,在骨组织工程、血管再生及神经组织等修复过程中均显示出了巨大的潜力,但胎盘间充质干细胞的具体应用机制目前尚不清楚,尚处于探索阶段,在胎盘间充质干细胞广泛应用于临床之前,仍有许多问题有待进一步研究明确,以确保其安全性和有效性。BACKGROUND：Placental mesenchymal stem cels are becoming a new source of seed cels because of wide range of sources, low immunogenicity and not involving ethical issues. OBJECTIVE：To elaborate the sources, biological characteristics and latest application of placental mesenchymal stem cels. METHODS：Literature search was performed in PubMed, ScienceDirect, OvidSP, CNKI databases for relevant literatures published from 2003 to 2015. The key words were “placenta, mesenchymal stem cels, placenta mesenchymal stem cels, cel transplantation, application mechanism” in Chinese and English, respectively. Then, 57 papers were further analyzed and reviewed in line with the theme. RESULTS AND CONCLUSION：Placental mesenchymal stem cels have been isolated and cultured successfuly, and confirmed to have multi-differentiation potential. A large number of placental mesenchymal stem cels have been used in the experimental animal and clinical researches, and they have a great potential in bone tissue engineering, revascularizaion and nerve repair. However, the specific mechanism underlying the application of placental mesenchymal stem cels is not clear. In order to ensure the safety and effectiveness, there are stil many problems to be further studied before placental mesenchymal stem cels are widely used in clinic.

关 键 词：干细胞 培养 胎盘 间充质干细胞 胎盘间充质干细胞 生物学特性 细胞移植 应用机制 文献综述 湖北省自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]