前白蛋白和视黄醇结合蛋白的测定及临床意义  

The Determination of Prealbumin and Retinol-binding protein and Their Clinical Significance

作　　者：王娜[1] 柳彦梅[1] 

机构地区：[1]商丘医学高等专科学校化学教研室,河南商丘476000

出　　处：《广东化工》2015年第17期125-125,128,共2页Guangdong Chemical Industry

基　　金：河南省商丘市科技攻关项目(编号:141055)

摘　　要：视黄醇结合蛋白(RBP)和前白蛋白(PA)是由肝脏合成的低分子量蛋白,血清RBP与视黄醇(维生素A)、前白蛋白(PA)形成RBP-Vit A-PA三元复合物,离开肝脏,释放入血液再进入各种组织。综述了RBP和PA常用的测定分析方法、原理以及测定的临床意义,由于RBP的半衰期较短,故在监测肾、肝及营养性疾病的发展方面,RBP比PA更为敏感。Retinol-binding proteins （RBP） and prealbumin （PA）are low molecular weight protein synthesized by the liver, serum RBPs, retinol （vitamin A） and prealbumin （PA） form to RBP-VitA-PA ternary complexes. After leaving the liver, Serum RBPs was released into blood streams, and then to various tissues. The article introduces the analysis methods principle and clinical significance of determination of two kinds of protein. Since the half-life peried of RBP is much shorter, the change of RBP can more sensitive than PA for detecting the development and the results of the diseases of kindey and liver, as well as nutritional diseases.

关 键 词：前白蛋白 视黄醇结合蛋白 半衰期 

分 类 号：S828.2[农业科学—畜牧学]