ASARM对骨骼矿化的影响  

Effect of ASARM on the bone mineralization

作　　者：吴博[1] 夏维波[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生和计划生育委员会内分泌重点实验室,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2015年第3期272-278,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金(81471088;81170805)

摘　　要：骨骼矿化是人体中重要的生理过程,主要由成骨细胞分泌形成细胞外基质,无机盐形成羟磷灰石结晶沉积在胶原纤维上而完成。矿化过程受多种因素调节,抗蛋白酶的酸性丝氨酸、天冬氨酸富集序列(proteaseresistant acidic serine-aspartate-rich motif,ASARM)是机体的蛋白降解产物,它对矿化的调节作用逐渐受到重视。遗传性低血磷性佝偻病/骨软化症的发病机制,可能与ASARM的异常调节有关。细胞外基质磷酸化糖蛋白(matrix extracellular phosphoglycoprotein,MEPE)及骨桥蛋白(osteopontin,OPN)经过降解后形成的ASARM(MEPE ASARM及OPN ASARM)可通过局部作用抑制矿化过程,而牙本质基质酸性磷蛋白-1(dentin matrix acidic phosphoprotein 1,DMP 1)和牙本质涎磷蛋白(dentin sialophosphoprotein,DSPP)降解后形成的ASARM(DMP1 ASARM及DSPP ASARM)对矿化可能存在促进作用。另外,ASARM也可通过其他途径影响激素分泌从而影响机体的系统性矿化。The bone mineralization is crucial important in physiological status. During the mineralization process,osteoblasts produce,secrete and form extracellular matrix,and then hydroxyapatite deposited on an collagen matrix. Mineralization is a complex regulated process,proteaseresistant acidic serine-aspartate-rich motif（ ASARM）,a kind of degradation products of protein,has been accepted as increasingly important mineralization modifier. Pathogenesis of oncogenic hypophosphatemic osteomalacia is possibly associated with dysregulation of ASARM. The matrix extracellular phosphoglycoprotein（ MEPE） and osteopontin（ OPN） degradation products-MEPE ASARM and OPN ASARM inhibite local mineralization,while dentin matrix acidic phosphoprotein 1（ DMP 1） and dentin sialophosphoprotein（ DSPP） degradation products-DMP1 ASARM and DSPP ASARM may play an positive role in the mineralization process. Moreover,ASARM could affect systemic mineralization of whole body as a consequence of secondary hormone secretion.

关 键 词：骨矿化 天冬氨酸富集序列(ASARM) 

分 类 号：R681[医药卫生—骨科学]