左卡尼汀治疗新生儿窒息后血浆肌钙蛋白I异常的效果  

Curative effect of L-carnitine on neonatal abnormal cardiac troponin I caused by asphyxia

作　　者：盛俞[1] 丛辉[2] 郭飞[1] 徐美玉[1] 张弘[3] 

机构地区：[1]南通大学附属医院儿科,226001 [2]南通大学附属医院检验科,226001 [3]南通大学附属医院消化病实验室,226001

出　　处：《天津医药》2015年第9期1034-1036,共3页Tianjin Medical Journal

基　　金：江苏省"六大人才高峰"资助项目(ws-066);南通大学自然科学项目(10Z060)

摘　　要：目的探讨左卡尼汀对新生儿窒息后受损害心肌的保护作用。方法窒息致心肌损害新生儿44例分为治疗组21例和对照组23例,2组患儿均予常规治疗,治疗组加用左卡尼汀针0.1 g/(kg·d)静脉滴注,每日1次,治疗7 d。观察治疗前以及治疗过程中患儿症状体征的变化。治疗前和治疗7 d后,试剂盒检测患儿静脉血血浆游离左卡尼汀和血浆肌钙蛋白I(c Tn I)水平。结果治疗组临床有效率明显高于对照组(90.48%vs 60.87%,P<0.05)。治疗后,治疗组游离左卡尼汀水平高于对照组[(27.00±5.69)μmol/L vs(13.20±3.04)μmol/L,P<0.05]。治疗组治疗后血浆游离左卡尼汀高于治疗前[(14.87±3.95)μmol/L,P<0.05]。治疗后,治疗组血浆c Tn I低于对照组[(0.025±0.006)μg/L vs(0.046±0.010)μg/L,P<0.05]。治疗组c Tn I下降值与游离左卡尼汀增加值之间有明显相关性(r=0.899,P<0.05)。结论左卡尼汀能有效降低有心肌损害的窒息新生儿异常血浆c Tn I水平,起到保护心肌的作用。Objective To explore the protective effect of L-carnitine on neonates with myocardial injury caused by asphyxia. Methods Forty-four neonates with myocardial injury caused by asphyxia were randomly divided into L-carnitine treatment group （21 cases） and control group （23 cases）. Patients in control group were received routine treatment and patients in treatment group were given L-carnitine 0. 1 g/（kg · d） on the basis of routine treatment for 7 days. Symptoms and physical signs were observed before therapy and during the treatment in two groups. Before and after the treatment, plasma levels of free L-carnitine and cardiac troponin I （cTnI） were detected with the method of colorimetric assay and chemiluminescent, respectively. Results The clinical effective rate was significantly higher in treatment group than that of control group （90.48%vs 60.87%, P〈0. 05）. Compared with the control group, there was a significantly higher plasma concentration of free L-carnitine in treatment group after treatment [（27.00±5.69）μmol/L vs （13.20±3.04）μmol/L, P〈0.05]. In treatment group, plasma concentration of free L-carnitine was significantly higher after treatment than that of pre-therapy [（14.87 ± 3.95）μmol/L,P〈0.05]. Compared with the control group, there was a significantly lower plasma concentration of cTnI after treatment in treatment group [（0.025±0.006）μg/L vs （0.046±0.010）μg/L, P〈0.05]. In the treatment group, there was a significant correlation between decreased plasma concentration of cTnI and increased plasma concentration of free L-carnitine （r=0.899, P〈0.05）. Conclusion Administration of L-carnitine can effectively decrease the abnormal plasma level of cTnI in neonates with myocardial injury caused by asphyxia, and thereby protect the myocardium.

关 键 词：窒息 新生儿 肌钙蛋白I 左卡尼汀 治疗结果 药物评价 

分 类 号：R722.12[医药卫生—儿科]