含三氧化二砷方案治疗复发难治性非M3急性非淋巴细胞白血病45例疗效观察  

Clinical analysis of As_2O_3 and low dose Homoharringtonine- cytarabine in the treatment of 45 patients with refractory or relapsed non- M3 acute non- lymphocytic leukemia

作　　者：姚亚洲[1] 李小妮[1] 郑引索 

机构地区：[1]宝鸡市中心医院血液风湿病科,陕西宝鸡721000

出　　处：《现代肿瘤医学》2015年第20期3030-3032,共3页Journal of Modern Oncology

摘　　要：目的回顾性分析三氧化二砷联合LD-HA治疗难治性非M3急性非淋巴细胞白血病的疗效及不良反应.方法：应用三氧化二砷（0.15mg·kg^-1·d^-1,d1～5,d8～12）＋LD-HA（高三尖杉酯碱1mg/d,阿糖胞苷25mg,2次/d,d1～14治疗.ANC（中性粒细胞计数）〈1.0×109/L时使用粒细胞集落刺激因子（G-CSF）5μg·kg^-1·d!1,直至ANC〉1.0×10^9/L.结果：一个疗程的总有效率达91.1%,其中CR32例（71.1%）,PR9例（20%）,NR4例（8.9%）.不良反应轻微.结论：三氧化二砷联合LD-HA治疗难治性非M3急性非淋巴细胞白血病安全有效.Objective:To observe the therapeutic outcome and adversere effect of the combined As2 O3 with low -dose homoharringtonine -cytarabine(LD -HA)in the treatment of refractory or relapsed non -M3 acute non -lym-phocytic leukemia.Methods:All the patients was treated with As2 O3 (0.15mg·kg-1 ·d-1 ,d1 ~5 ,d8 ~12 )and LD -HA with homoharringtonine 1mg/d and Ara -C 25mg,per 12h,d1 ~14 .Granulocyte colony -stimulating factor(G -CSF,5μg·kg-1 ·d-1 )was used when the absolute neutrophil count were counted less than 1.0 ×109 /L.Results:After one course of therapy,total efficiency rate of relapsed non -M3 acute non -lymphocytic leukemia was 91.1%, in which the complete remission (CR)were 32 cases(71.1%),partial response were 9 cases(20%),non -remis-sion were 4 cases(8.9%),without any great side effect.Conclusion:The combination of As2 O3 and LD -HA scheme had higher CR rate and fewer adverse action in the treatment of refractory or relapsed acute non -lymphocytic leuke-mia patients.

关 键 词：三氧化二砷 复发难治性急性非淋巴细胞白血病 疗效 

分 类 号：R733.71[医药卫生—肿瘤]