芽胞杆菌产生的环脂肽类物质的研究进展  

Advance in Cyclic Lipopeptide Substances from Bacillus subtilis

作　　者：周伟[1] 郑维[1] 陶思美 权春善[1] 范圣第[1] 

机构地区：[1]大连民族大学生命科学学院国家民委教育部重点实验室,辽宁大连116600

出　　处：《微生物学杂志》2015年第4期80-86,共7页Journal of Microbiology

基　　金：中央高校基本科研业务费专项资金资助项目(DC13010312;DC12010118)

摘　　要：环脂肽类物质具有抗菌、抗肿瘤、抗病毒等多种生物活性,其潜在的应用价值已逐渐引起了人们的注意。主要针对芽胞杆菌产生的环脂肽,综述了环脂肽类物质的结构及分类、生理活性、生物合成机制。由于环脂肽结构的不同,分离纯化及鉴定方法也会有所差异,因此对环脂肽的分离纯化及鉴定方法方面也做了简单的综述。最后展望了我国对于环脂肽研究的不足及未来的发展前景。Cyclic lipopeptide substances （ CLS） have antibiotic, antitumor and antiviral activities and many other bio-activities.Their potential applications have gradually attracted people’ attention.CLS from Bacillus subtilis mainly re-gards as the main subject in this article, their structure, classification, bio-activity and biosynthesis of CLS from B. subtilis are basically summarized.Different structure of CLS have different methods for isolation and purification, therefore, isolation and purification of CLS are simply summarized.Finally the deficiency and development outlook to come of CLS research in China were introduced.

关 键 词：枯草芽胞杆菌 环脂肽 化学结构 生物活性 生物合成 

分 类 号：Q939.93[生物学—微生物学]