CpG ODN免疫佐剂效应研究进展  

Progress on Immunoadjuvant Effect of CpG ODN

作　　者：董鹏[1,2] 程世鹏[2] 李真光[2] 杨洺扬 胡桂学[1] 冷雪[2] 

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118 [2]中国农业科学院特产研究所特种经济动物分子生物学国家重点实验室,吉林长春130122

出　　处：《动物医学进展》2015年第10期105-109,共5页Progress In Veterinary Medicine

基　　金：吉林省科技发展计划项目(20130522088JH;20140307008NY)

摘　　要：人工合成的含非甲基化CpG基序的寡聚脱氧核苷酸(CpG ODN)能够与树突状细胞、B细胞、单核细胞及巨噬细胞等免疫细胞内质网膜上的Toll样受体9(TLR-9)结合,通过产生Th1型免疫反应和分泌促炎因子来增强免疫应答的强度,在机体抵抗病原入侵和抗肿瘤等方面起到免疫增强剂的作用。近年来,CpG ODN作为一种新型免疫佐剂受到了人们越来越多的关注。论文主要介绍了CpG ODN的种类及其结构和功能特征、作用机制、对畜禽的免疫增强作用、安全性等方面的研究进展,为CpG ODN作为疫苗佐剂的进一步研究和在兽医临床上的应用提供参考。Synthetic oligodeoxynucleotides containing CpG motifs （CpG ODN）could combine with Toll-like receptor 9 （TLR-9）on endoplasmic reticulum from dendritic cells,B cells,monocytes and macrophages to mount an immune response characterized by the production of Th1 and proinflammatory cytokines,as an immune enhancer to resistance to pathogen invasion and antitumor in the hosts.In recent years,CpG ODN as a new immune adjuvant has received more attention.This article mainly introduced the research progress on the kinds of CpG ODN and its structure and function characteristics,mechanisms of action,immune en-hancement livestock and poultry in to strengthen and safety for CpG ODN as vaccine adjuvants to offer ref-erence to further research and its veterinary usage in clinic.

关 键 词：CPG寡核苷酸 免疫佐剂 效应机制 安全性 

分 类 号：S852.4[农业科学—基础兽医学]