急性心肌梗死患者血清同型半胱氨酸与冠状动脉狭窄程度及肌钙蛋白T的相关性  

Relationship among the homocysteine,the degree of coronary artery stenosis,and troponint in patients with acute myocardial infarction

作　　者：王霞[1] 闫业军[1] 李兴剑[1] 王頔[2] 

机构地区：[1]宝鸡市中心医院心内科,陕西宝鸡721008 [2]西安交通大学医学院病理学系

出　　处：《临床心血管病杂志》2015年第9期957-959,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨急性心肌梗死患者血清同型半胱氨酸(Hcy)与冠状动脉狭窄程度及肌钙蛋白T(cTnT)的关系。方法:入选122例发病24h以内的急性心肌梗死患者,根据入院时的血清同型半胱氨酸值分为两组:Hcy正常组(≤15μmol/L)和Hcy升高组(>15μmol/L)。采用循环酶法测定同型半胱氨酸、电化学发光法测定cTnT定量,同时作冠状动脉造影定量分析冠状动脉病变积分(CAS),以评价冠状动脉狭窄程度。结果:Hcy升高组和Hcy正常组的CAS无明显差别[(52.14±32.80)∶(50.61±36.64),t=0.539,P>0.05];Hcy升高组的cTnT要高于Hcy正常组,具有显著相关性[(3.98±1.52)mmol/L∶(1.99±1.79)mmol/L,t=2.448,P<0.05];两组cTnT的高低与Hcy水平呈正相关(r=0.498,P<0.05)。结论:血清Hcy可作为预测急性心肌梗死患者预后的一项重要指标,在治疗方面亦有重要临床意义;而与冠状动脉病变程度无明显关系。Objective：To study the relations among the Homocysteine（Hcy）,the coronary artery stenosis,and Troponin T（cTnT）in patients with acute myocardial infarction（AMI）.Method：The 122 patients with AMI onset in 12 hours were divided into two groups based on Hcy count（group A：Hcy≤15μmol/L,n=50;group B：Hcy15μmol/L,n=72）.Data of coronary stenosis score and quantity of cTnT in two groups were compared and analyzed.Result：There was no difference in coronary stenosis score between the two groups（52.14±32.80vs5 0.6 1±3 6.6 4,t=0.5 3 9,P〉0.0 5）.But quantity of cTnT in group B was higher than that of in group A[（3.98±1.52）mmol/L vs（1.99±1.79）mmol/L,t=2.448,P〈0.05],and Hcy counts had significant relationship with quantity of Troponin T（r=0.498,P〈0.05）.Conclusion：Hcy is an important indicator for predicting the prognosis and treatment,and has no relationship with the degree coronary stenosis score in AMI patients.

关 键 词：血清同型半胱氨酸 肌钙蛋白 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]