罗格列酮对糖尿病模型兔体质量、FPG及FFA等指标的影响  

Effects of Rosiglitazone on Body Weight,FPG,FFA and Other Indicators in Diabetes Model Rabbit

作　　者：占日新[1] 董芳[1] 来乐祥 张义林[1] 华铭[1] 

机构地区：[1]杭州市萧山区第四人民医院,杭州311225

出　　处：《中国药房》2015年第28期3929-3931,共3页China Pharmacy

基　　金：杭州市卫生科技计划项目(No.2013B57)

摘　　要：目的:研究罗格列酮(RH)对糖尿病模型兔体质量,空腹血糖(FPG)及游离脂肪酸(FFA)等的影响。方法:取18只兔随机均分为对照组、模型组、右旋糖酐组,后2组兔iv四氧嘧啶复制糖尿病模型,然后3组兔ig RH(0.5 mg/kg),其中右旋糖酐组兔给药同时iv右旋糖酐40葡萄糖注射液(5 ml/kg),每日1次,连续给药3周。检测给药前及给药后各组兔的体质量和血清中FPG、FFA、血管紧张素Ⅱ(AngⅡ)、NO水平。结果:与给药前比较,对照组兔给药后体质量增加,FFA、AngⅡ水平降低;模型组兔给药后FPG、FFA水平降低;右旋糖酐组兔给药后体质量降低,差异有统计学意义(P<0.01或P<0.05),其余指标差异无统计学意义(P>0.05)。其中,右旋糖酐组兔给药后FFA水平高于模型组,差异有统计学意义(P<0.01)。结论:罗格列酮可增加兔的体质量,其机制可能与降低FFA水平有关。OBJECTIVE：To study the effects of rosiglitazone（RH）on body weight,FPG,FFA and other indicators in diabe-tes model rabbit. METHODS：18 rabbits were evenly randomized into control group,model group and dextran group. The latter 2 groups were given alloxan intravenously to induce diabetes model. 3 groups were given RH（0.5 mg/kg）intragastrically,and dex-tran group was additionally given dextran 40 glucose injection（5 ml/kg）intravenously,once a day,for consecutive 3 weeks. Body weight,serum level of FPG,FFA,AngⅡ and NO were determined before and after medication. RESULTS：Compared with be-fore medication,body weight of rabbits in control group were increased after medication,while the levels of FFA and AngⅡ were decreased;the levels of FPG and FFA were decreased in model group;body weight of rabbits were decreased in dextran group af-ter medication,with statistical significance （P〈0.01 or P〈0.05）;other indicators had no statistically significant difference （P〉0.05）. The level of FFA in dextran group was higher than in model group after medication,with statistical significance（P〈0.01）. CONCLUSIONS：Rosiglitazone can lead to weight gain by a mechanism which reduce the level of FFA.

关 键 词：罗格列酮 兔 体质量 空腹血糖 游离脂肪酸 不良反应 

分 类 号：R965[医药卫生—药理学]