绝经前女性冠心病与免疫炎性反应相关因子的研究  

Study on immune inflammation reaction associated factors and premenopausal female coronary heart disease

作　　者：张秀云[1,2] 王学惠[2] 张永春[2] 娄婷叶[3] 

机构地区：[1]新乡医学院,河南新乡453000 [2]新乡医学院第一附属医院心血管内科,河南新乡453100 [3]新乡医学院第一附属医院检验科,河南新乡453100

出　　处：《检验医学与临床》2015年第18期2677-2679,共3页Laboratory Medicine and Clinic

基　　金：河南省科技攻关项目(320-2410)

摘　　要：目的探讨免疫炎性反应相关因子及雌激素水平与绝经前女性冠心病的关系,分析其临床特征及冠状动脉造影特点。方法按照入选标准选取2013年1月至2014年10月于新乡医学院第一附属医院心血管内科住院拟诊冠心病的绝经前女性43例,根据冠状动脉造影结果分为冠心病组(19例)和对照组(24例),均抽血测定免疫球蛋白IgG、IgA、IgM和补体C3、C4水平,同时检测超敏C反应蛋白及雌激素水平,观察冠心病患者的临床特征及冠状动脉病变特点。结果冠心病组IgG、hs-CRP水平显著高于对照组(P<0.05),IgM、IgA、C3及C4的水平显著高于对照组(P<0.05),冠心病组雌激素水平显著低于对照组(P<0.05);绝经前女性冠心病患者冠状动脉造影显示病变以单支病变为主,所占比例为58%,罪犯血管为左前降支者占79%。结论绝经前女性冠心病患者存在体液免疫功能亢进,hs-CRP水平升高及雌激素的缺乏与绝经前女性冠心病发生有关,其临床症状不典型,以单支血管病变为主,易累及左前降支。Objective To investigate the correlation between immune inflammation reaction associated factors and estrogen levels with premenopausal female coronary heart disease ,and to analyze its clinical characteristics and the coronary arteriographic features .Methods 43 premenopausal women patients diagnosed as coronary heart disease （CHD） in the First Affiliated Hospital of Xingxiang Medical College from January 2013 and October 2014 were seected according to the including criteria and divided into the CHD group（19 cases） and control group（24 cases） acording to the coronary angiography results .The levels of IgG ,IgA ,IgM ,complement C3 ,C4 ,hs‐CRP and E2 were detected .The clinical and angiographic features were observed .Results The IgG and hs‐CRP levels in the CHD group were significantly higher than those in the control group（P〈 0 .05） ,the IgM ,IgA ,C3 and C4 levels were significantly higher than those in the control group（P 〈 0 .05） ,while the E2 level in the CHD group was significantly lower than that in the control group （P 〈 0 .05） ;the coronary angiography in premenopausal women with CHD showed that the single vessel lesion was predominant ,accounting for 58% ,culprit vessel was left anterior descending coronary ,accounting for 79% .Conclusion The humoral immune hyperfunction exists in the premenopausal patients with CHD ,the elevation of hs‐CRP level and deficiency of E2 could be correlated with occurrence of CHD in premenopause women ,its clinical symptoms are atypical ,the single vessel lesion is predominant and the left anterior descending artery is most easily involved .

关 键 词：绝经前女性 冠心病 免疫炎性相关因子 雌激素 冠状动脉造影 

分 类 号：R814.43[医药卫生—影像医学与核医学]