Rh血型系统各抗原分布特点与恶性血液病的关系研究  

Study on distribution characteristics of Rh blood group antigens and their relationship with malignant hemopathy

作　　者：陆紫敏[1] 梁萍[1] 郑伟萍[2] 李雪晨[1] 方琦[1] 

机构地区：[1]同济大学附属同济医院输血科,上海200065 [2]同济大学附属同济医院检验科,上海200065

出　　处：《检验医学与临床》2015年第18期2680-2681,共2页Laboratory Medicine and Clinic

基　　金：上海市卫生和计划生育委员会科研课题资助项目(2010046);上海市公共卫生重点学科建设计划资助项目(12GWZX0202)

摘　　要：目的探讨Rh血型系统在恶性血液病中分布特点及相关性。方法采用血清免疫学方法对140例恶性血液病患者进行Rh血型系统表型鉴定并对其表型分布进行统计学分析。结果健康对照组Rh血型系统表型分布频率从高到低依次是CCDee>CcDEe>CCDEe>ccDEE>ccDEe>CcDee>CcDEE>ccDee=CCDEE,血液肿瘤组与健康对照组表型分布趋势不相一致,构成比差异有统计学意义(P<0.05),CcDee分布频率在健康对照组和血液肿瘤组间比较差异有统计学意义,相对危险度比值较高(OR=2.99);CCDee表型相对危险度比值较低(OR=0.61)。结论 Rh血型与恶性血液病的发生有一定关系,CcDee表型比较容易患恶性血液病,CCDee表型患恶性血液病风险明显低于Rh血型系统其他表型。Objective To investigate the distribution characteristics and correlation of Rh blood group system in malignant hemopathy .Methods The Rh blood phenotype identification in 140 patients with malignant hemopathy was performed by using the serological method and its phenotype distribution was statistically analyzed .Results The distribution frequency of Rh blood group phenotypes in the normal control group from high to low in turns was CCDee 〉CcDEe 〉CCDEe 〉ccDEE 〉ccDEe 〉CcDee 〉CcDEE 〉ccDee = CCDEE ;the distribution trend of Rh blood group phenotypes was significantly different between the malignant hemopathy patients and controls ,the differences were statistically significant （P〈 0 .05） ,the distribution frequency of CcDee type had statistically significant difference between the hemopathy group and the control group ,the relative risk ratio of CcDee type person suffering from malignant hemopathy was higher（OR = 2 .99） and the relative risk ratio that CCDee type person suffering from malignant hemopathy was lower（OR= 0 .61） .Conclusion There is certain relationship between the occurrence of malignant hemopathy and the Rh blood group .CcDee phenotype person is liable to suffer from malignant hemopathy ,the risk of CCDee type person suffering from malignant hemopathy is lower than that of other Rh group phenotypes .

关 键 词：恶性血液病 RH血型系统 相关性 

分 类 号：R457.11[医药卫生—治疗学]