血清胱抑素C、前清蛋白水平与T2DM患者早期肾脏疾病的相关性研究  

study on correlation between serum Cys C and prealbumin level with early kidney disease in patients with type 2 diabetes mellitus

作　　者：李艳丽[1] 廖勇敢[1] 李晓雯[1] 郑海燕[1] 汪茜[1] 陈思思[1] 黄明炜[1] 廖春分[1] 喻雄杰[1] 

机构地区：[1]湖北医药学院附属人民医院,442000

出　　处：《检验医学与临床》2015年第18期2708-2709,共2页Laboratory Medicine and Clinic

摘　　要：目的探究血清胱抑素C、前清蛋白的水平与老年2型糖尿病(T2DM)患者早期肾脏疾病的相关性。方法选取该院2012年2月至2014年1月确诊并收治的T2DM患者共130例,其中T2DM伴早期肾脏疾病者共70例,单纯T2DM患者60例,将其分为2组,通过实验室检查血清胱抑素C、前清蛋白的水平分析2项指标与T2DM患者早期肾脏疾病的相关性。结果 T2DM伴早期肾脏损伤者血清胱抑素C水平较单纯T2DM患者明显升高,其前清蛋白水平明显低于单纯T2DM患者,差异具有统计学意义(P<0.01)。结论血清胱抑素C、前清蛋白水平可以有助于监测和判断T2DM患者是否发生早期肾脏损伤,对T2DM伴肾脏损伤具有重要意义,具有较高临床价值,值得继续研究和应用。Objective To explore the correlation between cystatin C（Cys C） and prealbumin level with early kidney disease in elderly patients with type 2 diabetes mellitus（T2DM ） .Methods 130 cases of elderly （T2DM ） in our hospital from Feb .2012 to Jan .2014 were selected ,including 70 cases of T2DM complicating early kidney disease and 60 cases of simple T2DM ,they were divided into 2 groups .Then the Cys C and prealbumin levels were detected and their correlation with early kidney disease in the patients with T2DM was analyzed .Results The serum Cys C level in the patients with T2DM complicating early kidney damage was significantly increased compared with the patients with simple T2DM ,the prealbumin level was significantly lower than that in the patients with simple T2DM , the differences were statistically significant（P〈 0 .01） .Conclusion Serum Cys C and prealbumin levels can conduce to monitor and judge whether T2DM patients has early kidney injury ,has higher clinical value and deserves to be continuously researched and applied .

关 键 词：老年2型糖尿病 血清胱抑素C 前清蛋白 早期肾脏疾病 临床观察 

分 类 号：R692[医药卫生—泌尿科学]