丹红注射液对严重脓毒症凝血功能及预后的影响  

Effect of Danhong Injection on Severe Sepsis Blood Coagulation Function and Prognosis

作　　者：李志云[1] 杜仲平[2] 王春雨[3] 王恩燕[1] 戴坤鹏 王滨[1] 白桦[4] 

机构地区：[1]河北医科大学附属华北石油管理局总医院重症医学科,任丘062552 [2]甘肃省华亭县中医医院,华亭744100 [3]华北石油管理局中医医院,任丘062552 [4]中国中医科学院广安门医院南区,北京102618

出　　处：《世界中医药》2015年第8期1197-1200,共4页World Chinese Medicine

基　　金：北京市中医药科技项目(编号:JJ2012-50)

摘　　要：目的:探讨丹红注射液对严重脓毒症患者凝血功能及血乳酸的影响。方法:选择重症医学科收治的严重脓毒症患者100例,随机分为治疗组(n=52)和对照组(n=48),2组患者入院开始即给予充分的液体复苏、积极的抗感染治疗,必要时予血管活性药物、选择性的给予氢化可的松、呼吸机辅助通气等支持治疗,治疗组加用丹红注射液40 m L静脉滴注,1次/d。2组患者在入院时及入院第7天时监测急性生理学及慢性健康状况评分(APACHEⅡ评分)、凝血指标及血乳酸水平,并监测患者28 d死亡率。结果:2组患者入院第7天的凝血指标、血乳酸(Blood Lactic Acid,BLA)及APACHEⅡ评分比较均有统计学意义(P<0.05);患者28天死亡率治疗组比对照组低,但差异无统计学意义(P>0.05)。结论:丹红注射液可改善严重脓毒症患者凝血状态及低灌注缺氧代谢。Objective：To observe the effect of Danhong injection on blood coagulation function and blood lactic acid in patients with severe sepsis.Methods：A hundred patients with severe sepsis from the Intesive Care Unite were randomly classified into treat-ment group（n =52）and control group（n =48）.Patients in both groups were treated with fluid resuscitation,anti infection drugs at admission and given the vasoactive drug,hydrocortisone and mechanical ventilation support when necessary.The treatment group was treated with Danhong injection intravenous infusion of 40 mL once a day.APACHE Ⅱscore,blood coagulation indexes and blood lactic acid were measured at admission and the seventh day of hospitalization.The mortality was monitored at the 28th day of hospitalization.Results：The blood coagulation indexes,blood lactic acid and APACHE Ⅱscore of the treatment group and the control group were of significant difference at the seventh day（P 〈0.05）.The 28d mortality of the treatment group was lower than the control group,but the difference were not of statistically significance（P〉0.05）.Conclusion：Danhong injection can improve the blood coagulation state and decrease perfusion hypoxia in severe sepsis patients.

关 键 词：丹红注射液 严重脓毒症 凝血功能 血乳酸 

分 类 号：R259[医药卫生—中西医结合] R285.6[医药卫生—中医内科学]