美藤果油对高脂血症大鼠血脂的影响及对血管内皮细胞的保护作用  

Research on the Effect of Sacha Inchi Oil on Blood Lipid and Vascular Endothelial Cells in Hyperlipidemia Rats

作　　者：李伟[1] 王林元[1] 王景霞[1] 张建军[1] 王淳[1] 黄银峰[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《世界中医药》2015年第8期1227-1230,共4页World Chinese Medicine

基　　金：国家自然科学基金项目(编号:81273632)

摘　　要：目的:研究美藤果油对高脂血症模型大鼠血脂的影响及对血管内皮细胞的保护作用。方法:采用高脂饲料喂食复制大鼠高脂血症模型,以美藤果油灌胃给药4周,检测大鼠血清中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、内皮素1(ET-1)、一氧化氮(NO)、血栓烷素B2(TXB2)、6酮前列腺素(6-ketoPGF1a)的含量。结果:美藤果油能明显降低大鼠血清中TC、TG、LDL-C(P<0.01或P<0.05),对HDL-C含量影响不显著;美藤果油能明显降低血清中ET-1含量(P<0.01或P<0.05),显著升高NO的含量(P<0.001),对TXB2和6-ketoPGF1α含量影响不显著;美藤果油能恢复NO/ET-1和6-keto-PGF1α/TXB2的比值(P<0.01或P<0.05)。结论:美藤果油具有调节高脂血症模型大鼠血脂的作用,并可通过调节ET-1、NO的含量,恢复NO/ET-1和6-keto-PGF1α/TXB2的比值产生保护血管内皮细胞的作用。Objective：To study the effect of Sacha Inchi oil on blood lipid and vascular endothelial cells in hyperlipidemia rats. Methods：To build the model of hyperlipidemia rats by high fat diet,and then Sacha Inchi oil was given to the models by intragas-tric administration.The treatment lasted for 4 weeks.After the treatment,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,endothelin-1 （ET-1 ）,nitric oxide（NO）,throm-boxane B2 （TXB2 ）and the 6-keto-prostaglandin（6-keto-PGF1 a ）in serum were detected.Results：Sacha Inchi oli can reduce the levels of TC,TG and LDL-C significantly（P 〈0.01 or P 〈0.05）,and although Sacha Inchi oil had a positive effect on HDL-C, the result was not significant;Sacha Inchi oil could reduce the content of ET-1 （P 〈0.01 ,P 〈0.05）and increase the content of NO significantly（P 〈0.001 ）;Sacha Inchi oil had a positive effect on TXB2 ,6-keto-PGF1 α,but the result was not significant. Compared with the blank group,the ratios of NO/ET-1 and 6-keto-PGF1 α/TXB2 of the models increased significantly（P 〈0.001 or P 〈0.05）;Sacha inchi oil can restore the ratios of NO/ET-1 and 6-keto-PGF1 a /TXB2 （P 〈0.01 or P 〈0.05）.Conclusion：Sacha Inchi oil has an effect of regulating the lipid of hyperlipidemia rats,at the same time,it can regulate the content of ET-1 , NO in serum,restore the ratios of NO/ET-1 and 6-keto-PGF1 a /TXB2 ,and protect the vascular endothelial cells.

关 键 词：美藤果油 高脂血症 血脂 内皮素 一氧化氮 6 酮前列腺素 血栓素 2 

分 类 号：R285.5[医药卫生—中药学]