年龄对男性精液参数及DNA完整性的影响  

Effects of advanced paternal age on standard sperm parameters and sperm DNA integrity

作　　者：侯开波[1] 崔鑫[1] 任权[1] 

机构地区：[1]解放军第202医院全军优生优育计划生育技术研究所,辽宁沈阳110003

出　　处：《中国优生与遗传杂志》2015年第9期116-117,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨男性年龄与精子染色质结构完整性及精液常规参数的影响。方法选择男科门诊不育患者100人,依据年龄分成2组,小于40岁的青年组和大于40岁的中年组,分别观察两组患者的精液常规参数、精子形态学分析及精子染色质结构的完整性(DFI)。结果两组精子总数及形态学分析无明显差异,中年组的精子活力明显低于青年组,青年组精子染色质的完整性明显优于中年组。结论男性年龄的增大明显降低男性的生育能力,精子DNA完整性是评估男性生育能力的有力指标,高龄拟生育二胎男性应常规进行精液常规分析及DFI检查,发现异常及时处理,减少配偶异常妊娠及TTP等。Objective：To investigate the effects of advanced age on standard sperm parameters and sperm DNA integrity. Methods：Based on age,the infertile males were divided into two groups such as younger group（﹤40 years）and older group（≥40 years）. The main outcome measures included sperm DNA fragmentation index（%DFI,using sperm chromatin structure assay）,total sperm number,motility and morphology. Results：Total sperm number and morphology were not significantly different in these two groups. the prevalence of high levels of sperm DNA damage（% DFI）was significantly higher in older compared to younger men. progressive motility（%PR）was significantly higher in younger compared to older men. Conclusion：Advanced paternal age can significantly reduce fertility. The advanced couples should consider sperm DNA testing and the conventional semen analysis. Abnormal pregnancy and the time to pregnancy were notablely reduced.

关 键 词：精子 DNA碎片 年龄 不育 

分 类 号：R698.2[医药卫生—泌尿科学]