过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示  

Allergic diseases and intestinal flora imbalance for allergic constitution research

作　　者：杨菲[1] 王济[1] 王琦[1] 

机构地区：[1]北京中医药大学基础医学院中医体质与生殖医学研究中心,北京100029

出　　处：《北京中医药大学学报》2015年第8期509-514,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(No.81273611;No.81473554)

摘　　要：研究发现过敏性疾病与肠道菌群失调密切相关,其具体机制未明,西医学认为可能与树突状细胞等免疫细胞导致的肠道通透性增高、肠道屏障破坏相关。根据中医理论,可以认为与"肺脏受邪,传于大肠","脾脏受邪,营养受限,微环境骚动"和"肝脏受邪,风气内动,微环境骚动"3个原因相关,根本原因在于"邪气凑之,正气必虚"。结合中医体质学的4个基本原理"生命过程论""形神构成论""环境制约论""禀赋遗传论"探讨肠道菌群研究给中医过敏体质研究带来的启示。Studies have shown that intestinal flora imbalance is closely related with allergic diseases,yet its specific mechanism remains unclear.Modern medicine considers that it may be associated with in-creased intestinal permeability and intestinal barrier disruption caused by dendritic cells and other im-mune cells.Traditional Chinese Medicine identifies three possible approaches,which are “Lungs invaded by evil passing to the large intestine”,“Spleen invaded by evil leading to restricted nutrition and dis-turbed microenvironment”and “Liver invaded by evil leading to stirred-up wind and disturbed microenvi-ronment”.The root cause is that “Pathogenic factor invades when Zheng Qi is deficient”.This paper ex-plores what intestinal flora research can bring to the allergic constitution study by combining the four fun-damental theories “Life course theory”,“Composition of form and spirit”,“Environmental constraint theory”,and “Theory of innate endowment”.

关 键 词：过敏性疾病 食物过敏 肠道菌群 过敏体质 启示 

分 类 号：R2-031[医药卫生—中西医结合]