紫柏凝胶外治方治疗宫颈高危型人乳头瘤病毒感染的临床观察  

The effects of external use of Zibai Gel on cervical high-risk human papilloma virus infection: a clinical observation

作　　者：徐垲[1,2] 薛晓鸥[1] 马秀丽[1] 秦蕾[1] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]浙江省中医院

出　　处：《北京中医药大学学报》2015年第8期566-568,572,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：2011年北京市教委共建项目;2015年北京市科技计划十病十药研发项目

摘　　要：目的观察紫柏凝胶外治方治疗宫颈高危型人乳头瘤病毒(HPV)感染的疗效。方法收集宫颈高危型HPV感染的患者共85例,半随机方式分成2组,治疗组57例患者使用紫柏凝胶外治方治疗,对照组28例不使用任何药物治疗,进行临床观察比较。结果治疗组高危型HPV载量改善总好转56例(98.24%),对照组总好转9例(32.14%),2组间存在显著性差异(Z=-5.770,P<0.05)。治疗组临床表现总好转56例(98.24%),对照组总好转3例(10.71%),2组间存在显著性差异(Z=-7.485,P<0.05)。治疗组12例患者随访半年后,复查高危型HPV载量与治疗后复查的载量间未见显著性差异(Z=-0.405,P>0.05)。结论紫柏凝胶外治方能够明显降低宫颈高危型HPV载量,使部分高危型HPV感染转阴,随访半年未见复发,临床疗效肯定。Objective To observe the effects of external use of Zibai gel on cervical high-risk human papilloma virus （HR-HPV） infection.Methods 85 cases with cervical HR-HPV infection were recruited and then divided into two groups quasi-randomly.57 cases in the treatment group were applied with Zibai gel,while 28 cases in control group did not use any medication.The outcome was measured and observed.Results In the treatment group,the load of HR-HPV was reduced in 56 cases （98.24%）compared with only 9 cases （32.14%）in the control group.There was a significant difference between the two groups （Z = -5.770,P 〈0.05 ）.In the treatment group,clinical symptoms were relieved in 56 cases （98.24%）,compared with only 3 cases（10.71 %）in the control group.There was a significant difference between the two groups （Z =-7.485,P 〈0.05 ）.Cases of 12 patients from the treatment group were followed up after six months,and the load of HR-HPV showed no significant difference compared with those at the time right after the treatment （Z =-0.405,P 〉0.05）.Conclusion The external use of Zibai gel could reduce the load of HR-HPV, and convert some of high-risk HPV infection negative.According to the results in the six-month follow-up observation,the clinical effect was affirmative.

关 键 词：紫柏凝胶外治方 带下病 高危型人乳头瘤病毒 临床研究 

分 类 号：R271.917[医药卫生—中西医结合]