蓝光照射联合综合治疗对新生儿溶血症所致高胆红素血症患儿血清指标的调节作用  

Modulation effect of Blu-ray irradiation combining with comprehensive treatment on serum indicators of neonates with hyperbilirubinemia caused by hemolytic disease of newborn

作　　者：张莉[1,2] 镇祥繁[2] 李丹[2] 胡小燕[2] 

机构地区：[1]武汉大学基础医学院,湖北武汉430071 [2]湖北省松滋市人民医院新生儿科,湖北松滋434200

出　　处：《海南医学院学报》2015年第11期1551-1554,共4页Journal of Hainan Medical University

基　　金：湖北省科技计划项目(2012DJ3086)~~

摘　　要：目的:研究蓝光照射联合综合治疗对新生儿溶血症所致高胆红素血症患儿血清指标的调节作用。方法:80例新生儿溶血症所致高胆红素血症患儿随机分为两组,干预组接受蓝光照射联合综合药物治疗;对照组接受综合药物治疗。治疗前后分别检测血清中TBIL、MDA、神经功能相关分子、肝肾功能相关分子的含量。结果:治疗后,两组患儿血清中TBIL、MDA、MBP、S-100β、NSE、Cr、BUN、CysC、β2-MG、α-GST、GLDH含量均低于治疗前;干预组患儿血清中TBIL、MDA、MBP、S-100β、NSE、Cr、BUN、CysC、β2-MG、α-GST、GLDH含量均低于对照组(P<0.05)。结论:蓝光照射联合综合治疗能够更为有效的降低胆红素含量、保护神经功能、减轻氧化应激反应对肝肾功能的损伤,在新生儿溶血症所致高胆红素血症患儿的治疗中具有积极价值。Objective： To study the modulation effects of Blu-ray irradiation combining with comprehensive treatment on serum indicators of neonates with hyperbilirubinemia caused by hemolytic disease of newborn. Methods： 80 cases of neonates with hyperbilirubinemia caused by hemolytic disease of newborn were randomly divided into two groups. The intervention group received Blu-ray irradiation combining with comprehensive medication and control group received comprehensive medication. Before and after treatment, contents of serum TBIL, MDA, nerve function related molecules as well as liver and kidney function related molecules were detected. Results： After treatment, serum TBIL, MDA, MBP, S-10013, NSE, Cr, BUN, Cy-sC, β2-MG, α-GST and GLDH levels of both groups were lower than those before treatment. Serum TBIL, MDA, MBP, S- 1006, NSE, Cr, BUN, CysC, β2-MG, α-GST and GLDH levels of intervention group were lower than those of control group. Conclusion： Blu-ray irradiation combining with comprehensive treatment can more effectively reduce bilirubin level, protect nerve function and reduce oxidative stress damage to liver and kidney function. It has positive value in treatment of neonates with hyperbilirubinemia caused by hemolytic disease of newborn.

关 键 词：新生儿溶血症 高胆红素血症 蓝光照射 总胆红素 神经功能 

分 类 号：R722.18[医药卫生—儿科]