Hollow mesoporous Ia3d silica nanospheres with single- unit-cell-thick shell： Spontaneous formation and drug delivery application  

作　　者：Nienchu Lai Chihyu Lin Peihsin Ku Lilin Chang Kaiwei Liao Wunting Lin Chiamin Yang 

机构地区：[1]Department of Chemistry, Tsinghua University, Hsinchu 30013, Taiwan, China [2]Frontier Research Center on Fundamental and Applied Sciences of Matters, Tsinghua University, Hsinchu 30013, Taiwan, China

出　　处：《Nano Research》2014年第10期1439-1448,共10页纳米研究（英文版）

摘　　要：Mesoporous silica nanoparticles （MSNs） are promising for drug delivery and other biomedical applications owing to their excellent chemical stability and biocompatibility. For these applications, a hollow morphology with thin shell and open mesopores is preferred for MSNs in order to maximize the loading capacity of drugs. Herein we report a novel and direct synthesis of such an ideal drug delivery system in a dilute and alkaline solution of benzylcetyl- dimethylammonium chloride and diethylene glycol hexadecyl ether. The mixed surfactants can guide the formation of MSNs with cubic Ia3d mesostructure, and at a concentration of sodium hydroxide between 9.8 and 13.5 mM, hollow MSNs with uniform sizes of 90-120 nm and a single-unit-cell-thick shell are formed. A mechanism for the formation of the hollow Ia3d MSNs, designated as MMT-2, is proposed based on in situ small-angle X-ray scattering measurements and other analyses. MMT-2 exhibits much higher loading capacity of ibuprofen and degrades faster in simulated body fluid and phosphate buffered saline than non-hollow MSNs. The degradation of MMT-2 can be significantly retarded by modification with polyethylene glycol. More interestingly, the degradation of MMT-2 involves fragmentation instead of void formation, a phenomenon beneficial for their elimination. The results demonstrate the uniqueness of the hollow Ia3d MSNs and the great potential of the material for drug delivery and biomedical applications.Mesoporous 硅石 nanoparticles (MSN ) 由于他们的优秀化学稳定性和 biocompatibility 为药交货和另外的生物医学的应用程序是有希望的。为这些应用，有薄壳和开的 mesopores 的空形态学被比较喜欢让 MSN 以便最大化药的装载能力。此处，我们报导一篇小说和如此的一个理想的药交货系统的直接合成在一 dilute 和 benzylcetyldimethylammonium 氯化物和 diethylene 乙二醇 hexadecyl 醚的碱的答案。混合表面活化剂能与立方的 Ia3d mesostructure 指导 MSN 的形成，并且在在 9.8 和 13.5 公里之间的钠氢氧化物的集中，有 90120 nm 和 single-unit-cell-thick 壳的一致尺寸的空 MSN 被形成。为空 Ia3d MSN 的形成的机制，指定了为 MMT-2，被建议基于在 situ，散布大小和其它的小角度的 X 光检查分析。MMT-2 展出更高装载布洛芬的能力的大部分并且在模仿的身体液体和比非空的 MSN 盐的缓冲的磷酸盐更快降级。MMT-2 的降级能被修正显著地与聚乙烯乙二醇延迟。更有趣地， MMT-2 的降级包含破碎而不是空形成，为他们的消除有益的现象。结果为药交货和生物医学的应用表明空 Ia3d MSN 的唯一和材料的大潜力。

关 键 词：hollow mesoporous silica nanospheres cubic Ia3d mesostructure drug delivery silica degradation 

分 类 号：TQ575[化学工程—精细化工] TP391.75[自动化与计算机技术—计算机应用技术]