支原体肺炎患儿血清白介素6、肿瘤坏死因子-α、C-反应蛋白水平及临床意义  

Levels of serum IL-6,TNF-α and CRP in children with mycoplasma pneumoniae pneumonia and its clinical significance

作　　者：贺金娥[1] 高萃[1] 屈晖[1] 高春燕[1] 

机构地区：[1]延安大学附属医院儿科三病区,陕西延安716000

出　　处：《中国医药导报》2015年第27期106-108,共3页China Medical Herald

摘　　要：目的 探讨肺炎支原体肺炎（MPP）患儿血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）的水平变化及临床意义。方法 选择2013年1~12月延安大学附属医院儿科收治的MPP住院患儿60例作为病例组,并根据其治疗转归情况分为急性期及恢复期,选择同期门诊健康体检儿童55例作为对照组。测定各组患儿不同时期血清IL-6、TNF-α和CRP水平,并进行比较。采用Pearson相关性分析MPP患儿急性期血清CRP、IL-6、TNF-α水平的相关性。结果MPP患儿急性期血清IL-6[（56.21±19.27）ng/L]、TNF-o[（21.43±5.67）ng/L]和CRP水平[（28.35±7.79）mg/L]均高于同组恢复期[（15.52±5.91）ng/L、（9.31±4.93）ng/L、（6.04±1.11）mg/L]和对照组[（13.97±5.17）ng/L、（8.79±4.87）ng/L、（5.87±0.84）mg/L],差异均有统计学意义（P〈0.05）;病例组恢复期与对照组比较,差异无统计学意义（P〉0.05）。相关性分析显示,病例组急性期血清CRP水平与IL-6、TNF-α呈正相关（r=0.5596、0.5522,P〈0.05）,IL广6与TNF-α水平呈正相关（r=0.7426,P〈0.05）。结论IL-6、TNF-α和CRP参与患儿MPP的发病过程,动态监测血清IL-6、TNF-α和CRP的水平变化,有助于对MPP病情程度的判断与治疗效果的评价。Objective To investigate the levels of serum IL-6, TNF-α and CRP in children with mycoplasma pneumo- niae pneumonia （MPP） and its clinical significance. Methods From January to December 2013, in Department of Paedi- atrics, the Affiliated Hospital of Yan＇an University, 60 children with MPP were selected as case group. According to the treatment and prognosis of disease, children were divided into the acute stage and recovery stage. At the same time, 55 healthy children with physical examination in Outpatient Clinic were selected as control group. The serum levels of IL- 6, TNF-α and CRP in different groups and stages were detected and compared. Pearson test was applied to analyzed the correlation among levels of CRP, IL-6 and TNF-α. Results The serum levels of IL-6 [（56.21±19.27） ng/L], TNF-α [（21.43±5.67） ng/L] and CRP [（28.35±7.79） mg/L] of children with MPP in acute stage were significantly increased than those in recovery stage [（15.52±5.91） ng/L, （9.31±4.93） ng/L, （6.04±1.11） mg/L] and control group [（13.97±5.17） ng/L, （8.79±4.87） ng/L, （5.87±0.84） rag/L], the differences were statistically significant （P 〈 0.05）, but there was no significant difference between recovery stage and control group （P 〉 0.05）. Correlation analysis showed that serum level of CRP had positive correlation with IL-6 and TNF-α of children with MPP in acute stage （r = 0.5596, 0.5522, P 〈 0.05）; IL-6 and TNF-α had also positive correlation （r = 0.7426, P 〈 0.05）. Conclusion IL-6, TNF-α and CRP may be involved in the pathogenesis of MPP, and dynamic monitoring the changes of these cytokines can help to estimate the state and valuate therapeutic efficacy of MPP.

关 键 词：支原体肺炎 白介素-6 肿瘤坏死因子-Α C-反应蛋白 

分 类 号：R725.6[医药卫生—儿科]