抗β2糖蛋白Ⅰ抗体对自身免疫性溶血性贫血临床结局的影响  

Effect of Anti-beta2 Glycoprotein I Antibodies on Outcome of the Patients with Autoimmune Hemolytic Anemia

作　　者：曾晓虹[1] 薛原[2] 林珺芳[1] 郑玲[1] 康日辉[1] 

机构地区：[1]福建医科大学附属第一医院风湿科,福州350005 [2]厦门大学附属中山医院风湿免疫科,福建厦门361004

出　　处：《中华临床免疫和变态反应杂志》2015年第3期207-212,共6页Chinese Journal of Allergy & Clinical Immunology

摘　　要：目的评估抗β2糖蛋白I抗体(antiβ2 glycoproteinⅠ,aβ2GPI)与自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)临床结局的相关性。方法连续收集2008年12月至2013年4月在福建医科大学附属第一医院血液风湿科门诊和病房诊治的AIHA患者,包括继发于SLE的AIHA患者(SLE-AIHA组)和原发性AIHA患者(原发性AIHA组)。检测所有患者Ig G类抗β2GPI。采用SPSS11.5软件统计分析。结果共纳入AIHA患者42例,SLE-AIHA组22例,原发性AIHA组20例。SLE-AIHA组Ig G类抗β2GPI阳性患者溶血达部分缓解所需时间显著长于该抗体阴性患者,差异有统计学意义[(18±7)d vs.(13±4)d,P<0.05]。原发性AIHA组Ig G类抗β2GPI阳性组和阴性组患者溶血达部分缓解所需时间无统计学差异[(15±5)d vs.(11±3)d,P>0.05]。结论 Ig G类抗β2GPI可能是影响SLE并发AIHA预后的因素之一。Objective To assess the relationship of anti-beta2 glycoprotein I antibodies （anti-β2GPI） and the outcome of patients with autoimmune hemolytic anemia （AIHA）. Methods During December 2008 to April 2013, consecutive case series of patients with AIHA were studied in the First affiliated hospital of Fujian Medical university, Patients were classified as Primary autoimmune hemolytic anemia （Primary AIHA Group） and autoimmune hemolytic anemia secondary to SLE （SLE-AIHA Group）. Levels of IgG subtype anti-β2GPI were assessed in all cases. Data were analyzed by SPSS 11.5. Results A total of 42 patients with AIHA were enrolled in the study, 22 cases were primary AIHA, while 20 cases were SLE-AIHA. In the SLE-AIHA Group, patients with positive IgG subtype anti-β2GPI, revealed longer time in achieving partial remission than patients without the antibody [ （18 ± 7） d vs. （13±4） d, P 〈 0. 05 ]. In primary AIHA, there was no significant difference in the duration of achieving partial remission between patients with IgG subtype anti-β2GPI antibody and patients without IgG subtype anti-β2GPI [ （15 ± 5 ） d vs. （11±3） d, P 〉 0. 05 ]. Conclusion IgG subtype anti-132GPI antibody may be one of the factors related to the prognosis of patients with systemic lupus erythematosus complicated with autoimmune hemolytic anemia.

关 键 词：β2糖蛋白Ⅰ 自身免疫性溶血性贫血 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]