共振散射光谱法测定卡波姆  

Determination of Carbomer by Resonance Scattering Spectrometry

作　　者：叶秀金[1] 李俊健[1] 宋粉云[1] 

机构地区：[1]广东药学院药科学院,广州510006

出　　处：《理化检验（化学分册）》2015年第9期1286-1289,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：广东省自然科学基金资助项目(5002841)

摘　　要：基于卡波姆在强酸性介质中产生自聚集作用导致其共振散射光显著增强,建立了测定卡波姆的共振散射光谱法。在优化的试验条件下,卡波姆940,971P,974P质量浓度的线性范围分别为20~120mg·L^-1,50~300 mg·L^-1,20~300 mg·L^-1,检出限（3σ）分别为0.2,0.03,0.14μg·L^-1。方法用于样品分析,加标回收率在96.9%~100%之间,测定值的相对标准偏差（n=6）在1.2%~2.3%之间。A method of resonance light scattering spectroscopy was proposed for the determination of carbomer,based on the significant increases in the intensity of the resonance scattering light due to self-aggregations of carbomer in strong acid medium.Under optimized conditions,the linearity ranges of carbomer 940,971Pand974 Pwere 20-120mg·L^-1,50-300 mg·L^-1,and 20-300 mg·L^-1,respectively,and the detection limits（3σ）were 0.2,0.03,0.14μg· L^-1,respectively.The method was used to analyze samples,giving recovery rates in the range of 96.9%-100%,and RSD（n=6）in the range of 1.2%-2.3%.

关 键 词：共振散射光谱法 卡波姆 自聚集 

分 类 号：O657.3[理学—分析化学]