三苯氧胺对人胎盘绒毛滋养层细胞分泌功能的影响  

EFFECT OF TAMOXIFEN ON SECRETORY FUNCTION OF CHORIO-TROPHOBLASTIC CELLS FROM HUMAN PLACENTA

作　　者：韩桂珍[1] 褚云鸿[1] 周毓棻 周美华[1] 

机构地区：[1]上海医科大学基础部药理教研室,上海200032

出　　处：《中国临床药理学杂志》1991年第1期28-31,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：口服三苯氧胺和未服药的早孕妇女,经手术人工流产的胎盘绒毛组织,在无菌条件下进行体外培养。用RIA方法测定培液中孕酮和人绒毛膜促性腺激素(hCG)的含量。实验结果为:用药组孕酮、hCG的基础分泌量较未服药组显著为低(p<0.001)。促黄体素释放激素类似物(LHRH-A)能促进绒毛滋养层细胞孕酮、hCG的分泌,但用药组绒毛滋养层细胞对LHRH-A的反应性明显低于未服药对照组(p<0.01)。The chorio-trophoblastic cells in early pregnant womentaking orally tamoxifen and without tamoxifen were cultured in vitrounder aseptic condition. All pregnant women were aborted by suction cure-ttage. The concentration of progestcrone and hCG in the cultured humantrophoblastic cells were assayed by the radioimmunoassay technique. Theresults showed that basal levels of progesterone and hCG secretions bychorio-trophoblastic cells in the tamoxifen-treated group were significantlylowered when compared with those in the untreated controls (p<0. 001).LHRH-A could increase the amount of progesterone and hCG secreted bythe chorio-trophoblastic cells. The response of chorio-trophoblastic cellsto LHRH-A in the tamoxifen treated group significantly decreased whencompared with that in the untreated group (p<0. 01).

关 键 词：三苯氧胺 拮抗剂 孕酮 

分 类 号：R979.2[医药卫生—药品]