无创机械通气联合盐酸氨溴索治疗老年慢性阻塞性肺疾病临床疗效观察  

Clinical efficacy of noninvasive mechanical ventilation combined with ambroxol hydrochloride in the treatment for chronic obstructive pulmonary disease in the elderly patients

作　　者：赵洪达[1] 陈建波[1] 许群[1] 江莲[1] 

机构地区：[1]东南大学医学院附属江阴医院呼吸科,江苏省无锡市214400

出　　处：《实用老年医学》2015年第7期571-573,共3页Practical Geriatrics

摘　　要：目的探讨无创机械通气联合盐酸氨溴索对老年慢性阻塞性肺疾病(COPD)患者的临床疗效。方法选取我院2013年2月至2014年2月老年COPD呼吸衰竭患者60例,所有患者随机分为对照组和观察组,每组均为30例,2组患者均给予常规治疗(抗感染、解痉、吸痰、止咳、平喘等),对照组在此基础上结合呼吸机进行无创通气治疗,观察组在对照组的基础上,联合使用盐酸氨溴索针。治疗周期为10 d。观察临床治疗过程中2组患者的治疗有效率、肺功能、动脉血气变化情况等各项指标,并进行统计分析。结果观察组治疗有效率,动脉血氧分压(Pa O2),二氧化碳分压(Pa CO2),氧合指数(Pa O2/Fi O2),第1秒用力呼气容积/用力肺活量(FEV1/FVC)及用力呼气容积占预计值百分比(FEV1%)等各项指标显著优于对照组,差异具有统计学意义(P<0.05)。结论无创机械通气联合盐酸氨溴索对老年COPD患者临床效果好,值得临床上推广运用。Objective To evaluate the clinical efficacy of noninvasive mechanical ventilation combined with ambroxol hydrochloride in the treatment for chronic obstructive pulmonary disease（ COPD） in the elderly patients. Methods Sixty patients with COPD complicated with respiratory failure in our hospital from February 2013 to February 2014 were randomly divided into the control group（ n = 30） and the observation group（ n = 30）. Patients of two groups were given conventional treatment. The control group was treated with noninvasive ventilation therapy on the basis of the routine treatment,and the observation group was treated with ambroxol hydrochloride on the basis of the control group. The treatment course was 10 days. The clinical effect,pulmonary function,blood gas changes before and after treatment were determined. Results The clinical effect,arterial oxygen tension（ PaO2）,carbon dioxide partial pressure（ PaCO2）,oxygenation index（ PaO2/ FiO2）,FEV1 /FVC and FEV1% in observation group were more significantly improved than those in the control group（ P〈0. 05）. Conclusions Noninvasive mechanical ventilation combined with ambroxol hydrochloride shows good effects in the treatment for COPD in the elderly patients.

关 键 词：盐酸氨溴索 无创机械通气 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]