风湿性心脏病患者外周血CD3^+CD4^+T淋巴细胞与hs-CRP、IL-6表达的变化及意义  

The expression and clinical significance of CD3^+CD4^+T lymphocytes and hs-CRP and IL-6 in peripheral blood of rheumatic heart disease patients

作　　者：秦亚录[1] 许锋成 曾洪燕[1] 吴多江[2] 葛斌[3] 晏明君 余朝萍 杜曦[1] 汪斌[1] 刘天虎[1] 

机构地区：[1]成都郫县人民医院心内科,611730 [2]成都郫县人民医院科教科,611730 [3]成都郫县人民医院检验科,611730

出　　处：《重庆医学》2015年第27期3772-3774,共3页Chongqing medicine

基　　金：四川省卫生厅基金项目(120277)

摘　　要：目的探讨风湿性心脏病患者外周血CD3+CD4+T淋巴细胞表达与超敏C反应蛋白(hs-CRP)及IL-6的水平和意义。方法风湿性心脏病患者38例,健康者37例(对照),采用流式细胞术检测风湿性心脏病患者外周血CD3+CD4+T淋巴细胞表达水平,ELISA测定hs-CRP和IL-6的水平。结果风湿性心脏病患者外周血CD3+CD4+T淋巴细胞表达水平明显高于健康者(P<0.05)。风湿性心脏病患者外周血hs-CRP及IL-6水平明显高于健康者(P<0.05)。风湿性心脏病患者外周血CD3+CD4+T淋巴细胞表达水平与外周血hs-CRP、IL-6呈正相关关系(P<0.01)。结论 CD3+CD4+T淋巴细胞表达增高与风湿性心脏病的发病有关;风湿性心脏病患者外周血CD3+CD4+T淋巴细胞表达增高影响hs-CRP及IL-6,参与风湿性心脏病的发病。Objective To find out the changes of CD3^＋CD4^＋T lymphocytes,hs-CRP and IL-6in peripheral blood of the rheumatic heart disease（RHD）patients and to discover the relationship between the hs-CRP and IL-6.Methods The proportion of CD3^＋CD4^＋T lymphocytes in peripheral blood mononuclear cells（PBMCs）from 38 patients with RHD and 37 healthy peoples were analyzed by Flow cytometry.Concentration of hs-CRP and IL-6in serum from the same sample were tested the by ELISA.ResultsCompared with the healthy peoples,the proportion of CD3^＋CD4^＋T lymphocytes and the serum concentration of hs-CRP and IL-6were dincreased obviously in patients with RHD all（P〈0.05）.And the proportion of CD3^＋CD4^＋T lymphocytes were positive correlated with the concentration of hs-CRP and IL-6in RHD patients（P〈0.01）.Conclusion The increased expression of CD3^＋CD4^＋T lymphocytes may be associated with the pathogenesis of RHD that may affect the serum concentration of hs-CRP and IL-6in RHD patients.

关 键 词：CD3^+CD4^+T淋巴细胞 风湿性心脏病 超敏C反应蛋白 白介素-6 

分 类 号：R541.2[医药卫生—心血管疾病]