心音图D/S比值在慢性心力衰竭患者治疗中的随访价值  

The follow-up value of D/S ratio in CHF patients with treatment

作　　者：廖康腊[1] 秦俭[1] 廖慧[1] 罗素新[1] 郭兴明[2] 肖守中[3] 

机构地区：[1]重庆医科大学附属第一医院心内科,400016 [2]重庆大学生物工程学院重庆市医疗电子工程技术研究中心,400030 [3]博精医学与信息工程研究所,重庆400044

出　　处：《重庆医学》2015年第27期3779-3781,共3页Chongqing medicine

基　　金：国家临床重点专科建设项目经费资助(财社<2011>170号)

摘　　要：目的应用心音图舒张期时限/收缩期时限(D/S比值)评估慢性心力衰竭患者心力衰竭治疗前后的心功能情况,探讨心音图D/S比值在慢性心力衰竭患者治疗中的临床随访价值。方法收集重庆医科大学附属第一医院既往未正规治疗的CHF患者48例,予以常规抗心力衰竭治疗并随访3个月。治疗前后分别记录患者NYHA心功能分级、静息心率(RHR)、D/S比值、6min步行距离(6MWD)、左心室舒张末内径(LVEDd)及左心室射血分数(LVEF)。治疗3个月后以RHR 65次/min为界限,将CHF患者分为达标组与未达标组,比较各项指标治疗后的改善情况,比较D/S比值与常规心力衰竭评估指标的差异及各项指标与心功能缓解的关系。结果与用药前比较,除外RHR,未达标组治疗1个月时各项指标均无显著改善,治疗3个月后D/S比值、6MWD、LVEF有显著改善(P<0.05);达标组,治疗1个月时仅有D/S比值有显著改善(P<0.05),治疗3个月时各项指标均有显著改善(P<0.05)。两组组间比较,治疗1个月及3个月时RHR与D/S比值差异有统计学意义(P<0.05),LVEF在治疗3个月时差异有统计学意义(P<0.05)。同时D/S比值与6MWD同NYHA心功能分级呈显著负相关(P<0.05)。结论D/S比值可反映CHF患者抗心力衰竭治疗后心功能改善情况,在RHR控制达标者中能更早更显著反映出心功能的改善,在CHF患者抗心力衰竭治疗中具有良好的临床随访价值。Objective To explore the follow-up value of phonocardiogram D/S ratio in CHF patients with treatment.Methods Forty-eight CHF patients who had never under-went regular treatment were collected in our hospital,given the regular anti-heart failure treatment for 3months.NYHA heart failure classification,resting heart rate（RHR）,and D/S ratio of phonocardiogram were recorded,six-minutes walk distance（6MWD）,Left ventricular end diastolic diameter（LVEDd）,the left ventricular ejection（LVEF）were tested before and after treatment.After 3-month treatment,the resting heart rate 65 times as the watershed,the patients were classified into two groups：one was up to standard,and the other was not up to standard.D/S ratio,RHR,6MWD,LVEDD,LVEF and the improvement of the heart function were compared between the two group.Results Exception the resting heart rate,the indicators had no significant improvement in the group of not up to standard compared with the before treatment,and D/S ratio,6MWD,LVEF was improved significantly after three months treatment（P〈0.05）.In the group of up to standard,the D/S ratio was improved significantly after one months treatment（P〈0.05）,while after three months treatment all indicators were improved significantly（P〈0.05）.Comparison between the two groups,the RHR,D/S ratio were significantly improved（P〈0.05）,LVEF was significantly improved after three months treatment（P〈0.05）.At the same time,the D/S ratio,6MWD and NYHA classification of cardiac function was significant negatively correlated（P〈0.05）.Conclusion The D/S ratio could reflect heart functional improvements in patients with CHF after anti-heart failure treatment,and it could reflect the heart functional improvement earlier and more significant in the group up to standard,it has a good clinic follow-up value in CHF patients with anti-heart failure treatment.

关 键 词：心力衰竭 静息心率 舒张期时限与收缩期时限比值 

分 类 号：R541.6[医药卫生—心血管疾病]