2-甲氧基-4,6-二氯-1,3,5-三嗪的合成工艺优化  

Synthesis Process Optimization of 2-Methoxyl-4,6-dichloro-1,3,5-triazine

作　　者：张春仙[1] 

机构地区：[1]济宁学院化学与化工系,山东曲阜273155

出　　处：《化学世界》2015年第9期554-556,共3页Chemical World

摘　　要：三聚氯氰与甲醇发生SN2亲核取代反应,得到2-甲氧基-4,6-二氯-1,3,5-三嗪。通过采用正交试验,优化缚酸剂种类、缚酸剂用量、反应温度、反应时间等反应条件,确定了合成三聚氯氰甲氧基单取代产品的优化工艺为：以NaHCO3为缚酸剂、反应温度8~10℃、反应时间5h、三聚氯氰与缚酸剂物质的量之比为1∶1,目标产物的收率为84.4%。2-Methoxy-4,6-dichloro-1,3,5-triazine was prepared from cyanuric chloride and methanol by SN2 nucleophilic substitution reaction.The synthesizing processes of the mono-substituted hydrocarbon-oxygen 1,3,5-triazine was studied by orthogonal experiment.The influencing factors of the reaction,such as acid-capturer species,reaction time,temperature and so on were investigated.The experimental results showed that the optimal reaction conditions were as follows：the acid-capturer was NaHCO3,the molar ratio of cyanuric chloride and acid-capturer was 1∶1,the reaction temperature was controlled at 8~10℃,and the reaction time was 5h.The yield reached 84.4%.

关 键 词：三聚氯氰 2-甲氧基-4 6-二氯-1 3 5-三嗪 正交试验 

分 类 号：O621.3[理学—有机化学]