胞嘧啶的合成工艺改进  

Process Improvement on the Synthesis of Cytosine

作　　者：郭琳娜[1] 李欣倩[1] 毛武涛[1] 

机构地区：[1]南阳师范学院化学与制药工程学院,河南南阳473061

出　　处：《合成化学》2015年第9期858-860,共3页Chinese Journal of Synthetic Chemistry

基　　金：河南省高等学校重点科学研究项目(14A150047);南阳师范学院优秀博士科学研究资助计划(ZX2014047)

摘　　要：以氰乙酸乙酯、尿素、原甲酸三乙酯为原料,经缩合、环化和水解反应合成了5-羧基胞嘧啶(6);6经催化脱羧合成了胞嘧啶,总收率65.7%,其结构经1H NMR和ESI-MS确证。Cytosine was synthesized in total yield of 65.7% by decarboxylation of 5-carboxylcytosine, which was prepared by condensation, cyclization and hydrolysis, using triethyl orthoformate, urea and ethyl cyanoacetate as the starting materials. The structure was confirmed by ^1H NMR and ESI-MS.

关 键 词：胞嘧啶 5-羧基胞嘧啶 合成 工艺改进 

分 类 号：O626.41[理学—有机化学]