双水平气道正压通气治疗对重叠综合征患者血清同型半胱氨酸水平的影响研究  

Efficacy of Bi-level Positive Airway Pressure Treatment to Serum Homocysteine in Patients with Overlap Syndrome

作　　者：张敏[1] 黎燕群[1] 袁太文[1] 

机构地区：[1]赣州市人民医院呼吸内科,江西赣州341000

出　　处：《赣南医学院学报》2015年第4期550-552,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：2012年赣州市科技局指导性科技计划课题

摘　　要：目的:通过观察双水平气道正压通气(Bi PAP)治疗对重叠综合征(OS)患者血清同型半胱氨酸(HCY)的影响,以探讨Bi PAP治疗的疗效及可能的机理。方法:选取确诊为OS的患者31例,分别于Bi PAP治疗前及Bi PAP治疗1月时行7 h以上的夜间多导睡眠图(PSG)监测,并于次日清晨抽取静脉血测定血清HCY。比较患者治疗前后体重指数(BMI)、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(Mini SPO2)、夜间平均血氧饱和度(Mean SPO2)、HCY水平等指标,并对相应结果进行统计分析。结果:与治疗前比较,患者治疗1月后AHI、HCY均显著降低(P<0.01),Mini SPO2、Mean SPO2均显著升高(P<0.01)。结论:对OS患者合理进行Bi PAP治疗可降低其血清HCY水平。Bi PAP呼吸机辅助通气是一种治疗OS患者的有效方法。Objective： To explore the influence of bi-level positive airway pressure（ Bi PAP） treatment to homocysteine（ HCY） in patients with overlap syndrome（ OS） and the possible mechanisms. Methods： Thirty-one patients with OS were recruited. Before and on one months＇ Bi PAP treatment,a full-night（ more than 7 hours） polysomnography（ PSG）were performed and morning plasma concentrations of HCY were tested for the enrolled subjects. Body mass index（ BMI）,apnea-hypopnea index（ AHI）,nighttime minimum oxygen saturation（ Mini SPO2）,mean nocturnal oxygen saturation（ Mean SPO2）,HCY levels and other indicators were compared before and after treatment. Results： Compared with before treatment,there was a significant decrease in AHI,HCY and a remarkable increase in Mini SPO2,Mean SPO2 on one months＇ Bi PAP treatment in patients with OS（ all P 〈0. 01）. Conclusion： Bi PAP treatment leads to improvement of plasma HCY concentration and quality of life in patients with OS. Bi PAP mechanical ventilation shows to be an effective treatment in patients with OS.

关 键 词：阻塞性睡眠呼吸暂停综合征 慢性阻塞性肺疾病 重叠综合征 双水平气道正压通气 同型半胱氨酸 

分 类 号：R563.9[医药卫生—呼吸系统]