类孟买血型血清学鉴定及家系调查探讨  

Study on the serology identification of para-Bombay phenotype and the investigation of a family

作　　者：朱泽航[1] 陆元善[1] 

机构地区：[1]上海交通大学附属第一人民医院输血科,上海200080

出　　处：《检验医学》2015年第9期874-876,共3页Laboratory Medicine

摘　　要：目的探讨正确鉴定类孟买血型的方法,为罕见血型人群找寻更多相合供者。方法对4例正反定型不符者用ABO正反定型、Lewis血型鉴定、H抗原检测、红细胞吸收放散试验、冷抗体检测和检测唾液血型物质的中和抑制试验进行综合鉴定,并且进行家系调查。结果 4例被检者均证实为类孟买血型。先证者c的妹妹也被证实为同型类孟买型。结论对正反定型不一致的标本要高度警惕,应加做其它必要的血清学试验。冷抗体检测还能为类孟买血型患者辅助选择合适的血液输注。家系调查不仅能查清类孟买血型的来源和遗传,而且可以提供更多相同稀有血型供者。Objective To study the correct serology identification methods of para-Bombay phenotype and search compatible donors for rare blood type.Methods A total of 4 cases of positive and reverse typing discrepancy were identified comprehensively.ABO positive and reverse typing, Lewis blood type identification, H antigen detection, red blood cell absorption-elution test, cold antibody detection and hemagglutination inhibition test for blood type substance in saliva were performed.A family investigation was made.Results All the 4 cases were confirmed as para-Bombay phenotype.Proband c′s sister was also proved that she was the same para-Bombay phenotype.Conclusions The cases of positive and reverse typing discrepancy should be added other essential tests for para-Bombay phenotype.The detection of cold antibody assists in not only identifying para-Bombay phenotype but also selecting compatible blood for transfusion.Family investigation makes possible observe source and inheritance of para-Bombay phenotype and provide homogeneous donors for transfusion.

关 键 词：类孟买血型 ABD正反定型 H抗原 冷抗体 

分 类 号：R446.11[医药卫生—诊断学]