白癜风患者自身抗体及甲状腺激素检测的临床意义  

Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo

作　　者：吴俊琪[1] 姚爱萍 王美燕[1] 蒋亦秀 陆晓东[1] 

机构地区：[1]浙江大学金华医院检验科,浙江金华321000 [2]金华市第五医院皮肤科,浙江金华321000

出　　处：《检验医学》2015年第9期877-880,共4页Laboratory Medicine

基　　金：金华市科技局社会发展类重点科研项目(2010-3-056)

摘　　要：目的探讨白癜风患者血清中自身抗体和甲状腺激素的水平及临床意义。方法分别用间接免疫荧光法、免疫印迹法、化学发光法检测123例白癜风患者和60名正常对照者抗核抗体(ANA)、抗核抗体谱(ANAS)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TG-Ab)和甲状腺过氧化物酶抗体(TPO-Ab),并对白癜风组和正常对照组间的以上检测指标进行比较分析。结果白癜风组ANA、TG-Ab、TPO-Ab阳性率高于正常对照组(P均<0.01),ANAS阳性率2个组间比较差异无统计学意义(P>0.05);FT3、FT4水平2个组间比较差异无统计学意义(P均>0.05),TSH水平白癜风组高于正常对照组(P<0.05)。结论白癜风与甲状腺自身免疫性疾病之间关系密切,ANA、TG-Ab、TPO-Ab及TSH可作为白癜风患者伴有自身免疫性疾病的常用检测指标。Objective To investigate the levels and clinical significance of serum autoantibodies and thyroid hormone in patients with vitiligo.Methods The anti-nuclear antibody （ ANA ） , anti-nuclear antibody spectrum （ANAS）, free triiodothyronine （FT3）, free thyroxine （FT4）, thyroid stimulating hormone （TSH）, thyroglobulin antibody （ TG-Ab） and thyroid peroxidase antibody （ TPO-Ab） were determined in 123 patients with vitiligo and 60 healthy controls by indirect immunofluorescence, immunoblotting and chemiluminescence.The determination items were statistically compared between vitiligo group and control group.Results The positive rates of ANA, TG-Ab and TPO-Ab in vitiligo group were higher than those in control group（P〈0.01）, while ANAS was not statistically significant between the 2 groups （P〉0.05）.FT3 and FT4 were not statistically significant in the 2 groups（P〉0.05）.TSH in vitiligo group was higher than that in control group （P〈0.05）.Conclusions The relationship is close between vitiligo and thyroid autoimmune diseases.ANA, TG-Ab, TPO-Ab and TSH determinations can be usually used in vitiligo patients with autoimmune diseases.

关 键 词：自身抗体 甲状腺激素 自身免疫 白癜风 

分 类 号：R446.62[医药卫生—诊断学]