混合糖电解质用于肝胆手术后补液对血糖、炎症反应的影响  

Influence of Mixed Sugar Electrolyte on Blood Glucose and Inflammatory Reaction after Hepatobiliary Surgery

作　　者：张婷[1] 别玉坤[1] 王国辉[1] 冯以斌 

机构地区：[1]陕西省安康市中心医院,陕西安康725000

出　　处：《中国药业》2015年第19期78-79,共2页China Pharmaceuticals

摘　　要：目的观察混合糖电解质注射液用于肝胆手术后补液及对血糖、炎症反应的影响。方法选取行择期肝胆手术患者76例,随机分为对照组和观察组,各38例。对照组患者予以10%葡萄糖注射液联合10%氯化钾注射液及10%氯化钠注射液进行术后补液,观察组患者予以混合电解质注射液治疗。结果治疗第1天,两组患者血糖水平较前均明显升高(P<0.05),但组间未见明显差异(P>0.05);治疗第3天,两组患者血糖水平较治疗第1天均有所下降,但仅观察组有统计学差异(P<0.05)。两组患者术后C反应蛋白(CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平较前均有明显上升(P<0.05);治疗第3天,观察组患者CRP及TNF-α较对照组明显下降(P<0.05)。对照组患者全身炎症反应综合征(SIRS)发生率显著高于观察组患者(P<0.05)。两组患者不良反应发生情况比较无明显差异(P>0.05)。结论混合糖电解质注射液用于肝胆术后患者补液安全、有效,可临床推广。Objective To observe the influence of mixed glucose electrolyte injection on blood glucose and inflammatory reaction after hepatobiliary surgery. Methods ：76 cases of patients undergoing hepatobiliary surgery were selected and randomly divided into control group and observation group, 38 cases in each group. The control group was treated with 10% glucose injection combined with 10%KCl and 10% NaCl, and the observation group was treated with mixed electrolyte injection. Results On the first day of treatment, the blood glucose levels of the two groups were significantly higher than before（ P 〈 0. 05）, but there was no significant difference between the groups（P 〉 0.05）. On the third day of treatment, the blood glucose levels of the two groups decreased, but only the decrease in the observation group was with significant difference（P 〈 0.05）.The CRP, IL-6 and TNF-α of the two groups were significantly increased after treatment（ P 〈 0. 05）, and the CRP and TNF-α in the observation group were significantly lower than those in the control group on the third day of treatment（P 〈 0. 05）. The incidence rate of SIRS in the control group was significantly higher than that in the observation group（P 〈 0. 05）. There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0. 05）. Conclusion The treatment mixed sugar electrolyte injection after hepatobiliary surgery is safe and effective, and is worthy of clinical promotion.

关 键 词：混合糖电解质注射液 肝胆外科 血糖 炎症反应 术中配合 

分 类 号：R969.4[医药卫生—药理学] R977.7[医药卫生—药学]