阿立哌唑口腔崩解片治疗精神分裂症30例  

Aripiprazole for Treating Schizophrenia in 30 Cases

作　　者：于天凤[1] 

机构地区：[1]辽宁省沈阳市精神卫生中心,辽宁沈阳110168

出　　处：《中国药业》2015年第19期80-81,共2页China Pharmaceuticals

摘　　要：目的观察阿立哌唑口腔崩解片治疗精神分裂症的临床疗效及安全性。方法选择精神分裂症患者60例,采用随机数字表法分为观察组和对照组,各30例。对照组予利培酮口腔崩解片治疗,观察组予阿立哌唑口腔崩解片治疗。结果两组患者治疗后PANSS评分均较治疗前下降(P<0.05),但组间比较差异无统计学意义(P>0.05)。观察组治疗后4,8,12周血清催乳素水平分别为(14.82±4.18)ng/m L,(15.11±4.21)ng/m L,(15.25±4.28)ng/m L;分别显著低于对照组的(33.15±6.17)ng/m L,(51.73±6.98)ng/m L,(57.99±7.86)ng/m L(P<0.05)。治疗后8,12周TESS评分,观察组分别为(5.16±1.34)分和(4.34±1.01)分,未发生体重增加,肝功能异常1例,血糖升高3例;对照组治疗后8,12周TESS评分分别为(6.28±1.95)分和(5.27±1.76)分,发生体重增加11例,肝功能异常10例,血糖升高14例,组间对比差异有统计学意义(P<0.05)。结论阿立哌唑口腔崩解片与利培酮口腔崩解片治疗精神分裂症疗效相当,均可有效改善患者临床体征,但前者不良反应较少,对患者血清催乳素无明显影响,可提升患者生活质量与服药依从性,值得临床推广。Objective To observe the clinical efficacy and safety of aripiprazole in the treatment of schizophrenia. Methods 60 patients with schizophrenia were divided into observation group（ n =30） and control group（ n =30） according to random number table method, control group was given risperidone treatment, the observation group was given aripiprazole treatment. Results The PANSS scores of the two groups showed significant difference between before and after treantment（ P 〈 0.05）, but had no statistical significance difference between groups（P 〉 0.05）.4 weeks after treatment the serum prolaetin was （14.82 ±4. 18）ng/mL, 8 weeks after treatment the serum prolactin was （15. 11±4. 21）ng/mL, 12 weeks after treatment the serum prolaetin was （15.25 ±4.28）ng/mL, which were obviously lower than （33. 15±6.17）ng/mL, （51.73 ±6.98）ng/mL, （57.99± 7.86）ng/mL, respeatively（ P 〈 0.05）. TESS score of the observation group was （5.16 ±1.34） points after ＆ weeks, 12 weeks after treatment TESS score was （4. 34 ± 1.01）, no weight gain in observation group, 1 cases with abnormal liver function 3 cases, blood glucose after treatment for 8 weeks TESS sccore （6.28 ± 1.95） points, 12 weeks after treatment TESS score （5.27±1.76）mm, weight gain occurred in 11 cases, 10 cases of abnormal liver function, blood glucose, 14 cases of comparative differences between groups was statistically significant （P 〈 0.05）. Conclusion Aripiprazole and risperidone in the treatment of schizophrenia have similar curative effect, can effectively improve the clinical symptoms, while the former one has less adverse reaction, the patients serum prolactin has no obvious effect, can improve patients＇ quality of life and medication adherence, is worth popularizing in clinical use.

关 键 词：阿立哌唑口腔崩解片 利培酮口腔崩解片 精神分裂症 疗效 

分 类 号：R969.4[医药卫生—药理学] R971.41[医药卫生—药学]